pH-responsive delivery of anti-metastatic niclosamide using mussel inspired polydopamine nanoparticles

Mhatre, Omkar; Reddy, B. Pradeep K.; Patnaik, Chetna; Chakrabarty, Sabyasachi; Ingle, Aravind; De, Abhijit; Srivastava, Rohit

doi:10.1016/j.ijpharm.2021.120278

Cited by 7 publications

(12 citation statements)

References 46 publications

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“…To the best of our knowledge, this is the first study in which MSN-based Nic delivery has been reported. The amount of Nic loaded inside COOH-Chi-MSNs was 8.1 ± 1.3%, which is comparatively higher than the Nic loaded in polymeric micelles (∼1%) reported by Andrade et al and lower than the Nic loaded in polydopamine NPs (∼30%) reported by Mhatre et al 13,34 Moreover, Dox loaded in COOH-Chi-MSNs was 16.1 ± 0.6%, which is significantly higher than Dox loaded in chitosan-coated MSNs (1.39%) reported by Khatami et al and lower than Dox loaded in MSNs (∼61%) reported by Kajani et al 35,36 Furthermore, as evident by the imaging and flow cytometer-based uptake analysis, COOH-Chi-FMSNs were being internalized in all three breast cancer cell types in significant amounts. It is expected that NP-based delivery of drugs at the tumor site will minimize side effects and the requirement of repeated doses of free drugs.…”

Section: Discussioncontrasting

confidence: 55%

“…To date, very few NP-based Nic formulations have been developed, which include polymeric, lipid, and carbon NPs. 8,12,13 However, a mesoporous silica NPs (MSNs)-based pH-responsive Nic formulation has not been explored in spite of the known advantages of MSNs. As nanocarriers, MSNs offer several advantages such as large surface area, pore volume, easy and extensive surface modification, the ability to obtain controlled drug release kinetics, and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, loading hydrophobic drugs into NPs increases their stability, solubility and half-life in plasma and provides pharmacological benefits to the drug candidates such as Nic. To date, very few NP-based Nic formulations have been developed, which include polymeric, lipid, and carbon NPs. ,, However, a mesoporous silica NPs (MSNs)-based pH-responsive Nic formulation has not been explored in spite of the known advantages of MSNs. As nanocarriers, MSNs offer several advantages such as large surface area, pore volume, easy and extensive surface modification, the ability to obtain controlled drug release kinetics, and biocompatibility. , Therefore, to improve patient compliance and clinical translatability of the combination of Nic and Dox, in the present study, we proposed to develop an MSN-based combination therapy of Nic and Dox.…”

Section: Introductionmentioning

confidence: 99%

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Mesoporous Silica Nanoparticle-Based Combination of Niclosamide and Doxorubicin: Effect of Treatment Regimens on Breast Cancer Subtypes

Lohiya

Katti

2021

ACS Appl. Bio Mater.

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Overexpressed Wnt/β-catenin signaling acts as a major cancer driver and plays an important role in the development of resistance against cancer chemotherapy. Therefore, the combinatorial approach of downregulating Wnt/βcatenin signaling along with using a chemotherapeutic agent may improve cancer therapy. However, systemic administration of free anticancer agents is nonspecific and poses serious side effects. Hence, the present study aimed at developing mesoporous silica nanoparticle (MSN)-based targeted combination therapy of a Wnt signaling inhibitor, niclosamide (Nic), and a conventional anticancer agent, doxorubicin (Dox). The results demonstrated the reproducible synthesis of highly stable and monodispersed sub-100 nm spherical shaped NPs. In vitro cytotoxicity studies demonstrated that the individual drug formulations caused concentration-dependent cytotoxicity to all of the three breast cancer subtypes, with higher concentrations being more cytotoxic. Further, sequential and concurrent combination of Nic-loaded MSNs with Dox-loaded MSNs was synergistic and caused significantly enhanced death in all breast cancer subtypes. Quantification of the combinatorial efficacy suggested that multiple combinatorial pairs were synergistic in all of the breast cancer types for both (sequential and concurrent) treatment regimens. However, the extent of synergism varied between the two treatment regimens in different clinical subtypes of breast cancer. Overall, the combination of Nic-loaded MSNs with Dox-loaded MSNs holds promise to be developed as an efficient therapeutic option for breast cancer irrespective of the clinical subtype in both sequential and concurrent treatment regimens.

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesoporous Silica Nanoparticle-Based Combination of Niclosamide and Doxorubicin: Effect of Treatment Regimens on Breast Cancer Subtypes

Lohiya

Katti

2021

ACS Appl. Bio Mater.

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“…PDA NP has been utilized in biomedical engineering, semiconductor physics, material science, and chemistry 15 . PDA NP is mainly employed in biomedical engineering in cancer therapeutics, bacterial and fungal infections, neuronal diseases, sensing, and imaging 16–18 . The PDA NP alone will not serve as a therapeutic agent; it must conjugate with drugs, photosensitizers, metals, or metallic nanoparticles 13,18,19 .…”

Section: Introductionmentioning

confidence: 99%

Polydopamine nanocomposites and their biomedical applications: A review

Chinchulkar

Patra

Dehariya

et al. 2022

Polymers for Advanced Techs

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Polydopamine (PDA) is the end product of the dopamine monomer's self‐oxidation polymerization process. PDA is gaining popularity in diagnostic and therapeutic purposes because of its unique properties like excellent biocompatibility, biodegradability, surface functionalization, adhesion, and photothermal, which can help in various biomedical applications. Many researchers have been working on polydopamine nanocomposites in recent years. PDA has been used to modify various structures, such as metal nanoparticles, in order to improve the nanosystem's stability and applicability. This review attempts to cover extremely recent works from 2018 to the present in light of recent developments in PDA nanocomposites. The development of novel PDA nanocomposites for therapeutic applications, such as PDA‐metal, PDA‐drug, PDA‐photosensitizers, and PDA‐biomolecules, has been covered in this review. The multiple biomedical applications highlighted in this review include the treatment of cancer, antimicrobial infections, and neurological disorders, as well as wound healing and biosensing. This review will not only help the new researcher to build their base but also for experts to extend their views in this field.

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“…Among the various FDA-approved drug candidates, the anthelminthic drug Niclosamide [12] (NIC; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide) has been found to possess superior in vitro anti-viral effects [13], throwing light on the fact that it could be potentially useful for treating COVID-19. NIC could act through two major pharmacological pathways.…”

Section: Introductionmentioning

confidence: 99%

Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment

Piao

Rejinold

et al. 2021

Polymers

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Niclosamide (NIC), a conventional anthelmintic agent, is emerging as a repurposed drug for COVID-19 treatment. However, the clinical efficacy is very limited due to its low oral bioavailability resulting from its poor aqueous solubility. In the present study, a new hybrid drug delivery system made of NIC, montmorillonite (MMT), and Tween 60 is proposed to overcome this obstacle. At first, NIC molecules were immobilized into the interlayer space of cationic clay, MMT, to form NIC–MMT hybrids, which could enhance the solubility of NIC, and then the polymer surfactant, Tween 60, was further coated on the external surface of NIC–MMT to improve the release rate and the solubility of NIC and eventually the bioavailability under gastrointestinal condition when orally administered. Finally, we have performed an in vivo pharmacokinetic study to compare the oral bioavailability of NIC for the Tween 60-coated NIC–MMT hybrid with Yomesan®, which is a commercially available NIC. Exceptionally, the Tween 60-coated NIC–MMT hybrid showed higher systemic exposure of NIC than Yomesan®. Therefore, the present NIC–MMT–Tween 60 hybrid can be a potent NIC drug formulation with enhanced solubility and bioavailability in vivo for treating Covid-19.

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pH-responsive delivery of anti-metastatic niclosamide using mussel inspired polydopamine nanoparticles

Cited by 7 publications

References 46 publications

Mesoporous Silica Nanoparticle-Based Combination of Niclosamide and Doxorubicin: Effect of Treatment Regimens on Breast Cancer Subtypes

Mesoporous Silica Nanoparticle-Based Combination of Niclosamide and Doxorubicin: Effect of Treatment Regimens on Breast Cancer Subtypes

Polydopamine nanocomposites and their biomedical applications: A review

Niclosamide–Clay Intercalate Coated with Nonionic Polymer for Enhanced Bioavailability toward COVID-19 Treatment

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