pH-responsive controlled release of mesoporous silica nanoparticles capped with Schiff base copolymer gatekeepers: Experiment and molecular dynamics simulation

Peng, Shiyuan; Yuan, Xiaozhe; Lin, Wenjing; Cai, Chengzhi; Zhang, Lijuan

doi:10.1016/j.colsurfb.2019.01.024

Cited by 49 publications

(10 citation statements)

References 55 publications

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“…Obtained DOX delivery system made it possible to interrupt premature release of encapsulated drug before reaching the colon, as was desired. Another example of delivery system for DOX is MSN modified by amphiphilic block copolymer poly(poly(ethylene glycol) methylether methacrylate-co-p-(2-methacryloxyethoxy)benzaldehyde) [210]. The system formed is capable to release content at pH 5.0 (64% of released drug from the total amount after 72 h) and effectively penetrate into HepG2 cells (Figure 16).…”

Section: Mesoporous Silica Nanoparticles Modified By Synthetic Polymersmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

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Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.

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Section: Mesoporous Silica Nanoparticles Modified By Synthetic Polymersmentioning

confidence: 99%

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Kashapov

Ibragimova

Pavlov

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Bonds between the gatekeeper molecules and the MSNs themselves could be chosen for their response to acidic pH as well, largely resulting in dissociation of gatekeeper molecules from the MSN surface. Examples of such formulations can utilize imine bonds [150][151][152], ester bonds [150,153,154], or hydrazine bonds [155], among others [147]. In all these cases, the gatekeeper molecule is organic in nature, improving biocompatibility between the MSN nanovehicle and the host while limiting toxicity.…”

Section: Molecular Encapsulation and Stimuli-specific Release Responsementioning

confidence: 99%

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

et al. 2021

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Due to the theragnostic potential of mesoporous silica nanoparticles (MSNs), these were extensively investigated as a novel approach to improve clinical outcomes. Boasting an impressive array of formulations and modifications, MSNs demonstrate significant in vivo efficacy when used to identify or treat myriad malignant diseases in preclinical models. As MSNs continue transitioning into clinical trials, a thorough understanding of the characteristics of effective MSNs is necessary. This review highlights recent discoveries and advances in MSN understanding and technology. Specific focus is given to cancer theragnostic approaches using MSNs. Characteristics of MSNs such as size, shape, and surface properties are discussed in relation to effective nanomedicine practice and projected clinical efficacy. Additionally, tumor-targeting options used with MSNs are presented with extensive discussion on active-targeting molecules. Methods for decreasing MSN toxicity, improving site-specific delivery, and controlling release of loaded molecules are further explained. Challenges facing the field and translation to clinical environments are presented alongside potential avenues for continuing investigations.

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“…The force field parameters for DOX and RHE molecules were obtained from the generalized Amber force field (GAFF). The atomic charges were generated with the restrained electrostatic potential (RESP) method [35]. An artificial box containing 8 DOX, 8 RHE and 2000 water molecules was generated using the leap module in Amber Tools.…”

Section: Molecular Dynamics (Md) Simulationsmentioning

confidence: 99%

Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions

et al. 2020

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Background: The management of metastatic cancer remains a major challenge in cancer therapy worldwide. The targeted delivery of chemotherapeutic drugs through rationally designed formulations is one potential therapeutic option. Notably, excipient-free nanodispersions that are entirely composed of pharmaceutically active molecules have been evaluated as promising candidates for the next generation of drug formulations. Formulated from the self-assembly of drug molecules, these nanodispersions enable the safe and effective delivery of therapeutic drugs to local disease lesions. Here, we developed a novel and green approach for preparing nanoparticles via the selfassembly of rhein (RHE) and doxorubicin (DOX) molecules, named RHE/DOX nanoparticles (RD NPs); this assembly was associated with the interaction force and did not involve any organic solvents. Results: According to molecular dynamics (MD) simulations, DOX molecules tend to assemble around RHE molecules through intermolecular forces. This intermolecular retention of DOX was further improved by the nanosizing effect of RD NPs. Compared to free DOX, RD NPs exerted a slightly stronger inhibitory effect on 4T1 cells in the scratch healing assay. As a dual drug-loaded nanoformulation, the efficacy of RD NPs against tumor cells in vitro was synergistically enhanced. Compared to free DOX, the combination of DOX and RHE in nanoparticles exerted a synergistic effect with a combination index (CI) value of 0.51 and showed a stronger ability to induce cell apoptosis. Furthermore, the RD NP treatment not only effectively suppressed primary tumor growth but also significantly inhibited tumor metastasis both in vitro and in vivo, with a better safety profile. Conclusions: The generation of pure nanodrugs via a self-assembly approach might hold promise for the development of more efficient and novel excipient-free nanodispersions, particularly for two small molecular antitumor drugs that potentially exert synergistic antiproliferative effects on metastatic breast cancer.

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pH-responsive controlled release of mesoporous silica nanoparticles capped with Schiff base copolymer gatekeepers: Experiment and molecular dynamics simulation

Cited by 49 publications

References 55 publications

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

Synergistic inhibition of metastatic breast cancer by dual-chemotherapy with excipient-free rhein/DOX nanodispersions

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