pH-responsive casein-based films and their application as functional coatings in solid dosage formulations

Picchio, Matías L.; Paredes, Alejandro J.; Palma, Santiago Daniel; Passeggi, M. C. G.; Gugliotta, Luis Marcelino; Minari, Roque Javier; Igarzabal, Cecilia Inés Álvarez

doi:10.1016/j.colsurfa.2018.01.012

Cited by 19 publications

(7 citation statements)

References 38 publications

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“…Also, phase aggregation was not distinguished throughout the films, indicating that components achieved a high compatibilization and a restricted mobility of protein during film formation. 12,13,32 This observation is in agreement with the high compatibility indicated from the high PGE values (Table 2). In contrast, AFM images for film surface obtained from the physical mixture PMix presented a continuous hard phase with the presence of big and irregular aggregates of acrylic particles (Figure S5 of the SI), due to the lack of compatibilization between proteins and the acrylic polymer, as it was shown in Table S1 of the SI.…”

Section: Resultssupporting

confidence: 89%

Waterborne Hybrid Acrylic/Protein Nanocomposites with Enhanced Hydrophobicity by Incorporating a Water Repelling Protein

Allasia

Passeggi

Gugliotta

et al. 2019

Ind. Eng. Chem. Res.

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The incorporation of natural proteins as a renewable resource in the production of hybrid latexes has high interest in academia and industry, due to the opportunity to synthesize novel eco-friendly materials with special functionalities, improved properties, and biodegradable character. This article pursues the synthesis by miniemulsion polymerization of novel waterborne nanoparticles which adequately combine 3 main components: (i) a low T g acrylic copolymer that provides controllable mechanical properties; (ii) casein, an amphiphilic protein that allows polymer particle stabilization without employing an emulsifier, which means a challenge for producing stable polymer dispersions; and (iii) zein, a water repelling protein which balances the hydrophilic character of casein. The obtained emulsifier-free hybrid latexes present high compatibility among components, resulting in new materials with improved properties. Hybrid films formed exhibit enhanced water resistance when incorporating a very low fraction of zein (5% with respect to the total protein content) and a hydrophobic surface with a contact angle similar to the pure acrylic film (82°). The main characteristics of hybrid nanoparticles and relevant properties of obtained films are discussed here.

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Section: Resultssupporting

confidence: 89%

Waterborne Hybrid Acrylic/Protein Nanocomposites with Enhanced Hydrophobicity by Incorporating a Water Repelling Protein

Allasia

Passeggi

Gugliotta

et al. 2019

Ind. Eng. Chem. Res.

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“…Although vinyl monomers (e.g. methyl methacrylate, butyl acrylate, and caprolactam) 7–9 , crosslinking agent 10–13 or polyurethane 14,15 have been grafted to the α-C or N of casein structure, which can introduce new components and block some hydrophilic groups of casein structure, resulting in high hydrophobicity and mechanical tensile strength and elasticity of the casein films. However, it involves harsh reaction conditions and environmental concerns.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of homogeneous and enhanced casein protein-based composite films via incorporating cellulose microgel

Yao

Hong-ru

Wang

et al. 2019

Sci Rep

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Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and significantly reduces the moisture absorption of the composite films, as well as a decrease in the water vapor permeability with an increase of GCC content at different relative humidity is also observed. Compared with pure casein material, the resultant CA-based composite films show more homogeneous and dense cross-sectional structure, and the cleavage temperature of the hydrogen bonds increases by 16 °C. In particular, their tensile strength and Young’s modulus increase by 6 and 3.5 times, respectively. These indicators are superior to that of the nanoparticle enhanced CA-based composite film. Moreover, the light transmittance of the CA-based films at 550 nm is about 88% when GCC content is higher than 9%. The above results could be attributed to the strong hydrogen bonds formed between GCC components and CA matrix, as further confirmed by fourier transform infrared spectra and X-ray diffraction analysis.

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“…The first swelling step can be related to the expansion of the microstructure and the second step to the complete disintegration of the entire particle 25 . Casein films cross-linked with high methacrylated casein also showed stronger swelling in alkaline medium compared to those in acidic media 31 . In addition, the swelling kinetics also showed overshooting, which can also be observed with CMPs, but only if covalent cross-links with transglutaminase were subsequently inserted 32 .…”

Section: Introductionmentioning

confidence: 91%

Citrate effect on the swelling behaviour and stability of casein microparticles

Asaduzzaman

Pütz

Gebhardt

2022

Sci Rep

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Casein microparticles obtained from casein micelles by volume exclusion of added pectin and subsequent film drying remain stable in the acidic and neutral pH range, but swell strongly in the basic range. Calcium significantly impacts on the stability and water-binding behavior of phosphorylated caseins and the aggregates and gels formed from them. For a future effective and controlled use as a carrier for bioactive substances, e.g. via the gastrointestinal tract, we therefore investigated how the addition of the calcium chelating agent citrate affects the swelling and stability of the microparticles. Citrate concentrations of 2 mM and above cause a stronger swelling of the microparticles at pH 8, while above 4 mM the second characteristic swelling step starts earlier and thus can also be investigated within the observation time of 120 min. All swelling kinetics can be simulated using seven parameters of a dynamic model, which reproduces the individual swelling steps via volume inflows and outflows into a reservoir. While the rate coefficient for swelling step 1 increases linearly with citrate concentration, no such dependence could be found for swelling step 2. The more citrate is used, the faster the microparticles decompose in turbidity experiments after the addition of sodium dodecyl sulfate, which can be related to a weakening of the hydrophobic interactions.

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pH-responsive casein-based films and their application as functional coatings in solid dosage formulations

Cited by 19 publications

References 38 publications

Waterborne Hybrid Acrylic/Protein Nanocomposites with Enhanced Hydrophobicity by Incorporating a Water Repelling Protein

Waterborne Hybrid Acrylic/Protein Nanocomposites with Enhanced Hydrophobicity by Incorporating a Water Repelling Protein

Preparation and characterization of homogeneous and enhanced casein protein-based composite films via incorporating cellulose microgel

Citrate effect on the swelling behaviour and stability of casein microparticles

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