pH-responsive Astragalus polysaccharide-loaded PLGA nanoparticles as an adjuvant system to improve immune responses

Xu, Shuwen; Feng, Zian; Zhang, Yue; Ni, Haiyu; Liu, Zhenguang; Wang, Deyun

doi:10.1016/j.ijbiomac.2022.09.283

Cited by 6 publications

(9 citation statements)

References 30 publications

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“…Importantly, the OVA-loaded pH-responsive APSPs have shown low cell toxicity and markedly enhanced the expression of MHC-II, CD80, CD86 and the phagocytic capability of macrophages . Compared with APS alone, this design scheme can stimulate stronger Th1-biased immune responses and enhance the abilities of cellular and humoral immunity in early immunity . In addition, for achieving to control release of DNA vaccine, Lu et al have engineered a PEG- g -PEI/DNA nanoparticle-in-PLGA “microsphere” hybrid controlled release system .…”

Section: Ph-sensitive Polymeric Nanovaccinesmentioning

confidence: 99%

“…117 Compared with APS alone, this design scheme can stimulate stronger Th1-biased immune responses and enhance the abilities of cellular and humoral immunity in early immunity. 60 In addition, for achieving to control release of DNA vaccine, Lu et al have engineered a PEG-g-PEI/DNA nanoparticle-in-PLGA "microsphere" hybrid controlled release system. 59 Lyophilized PEG-g-PEI/DNA NPs obtained from PEI and polyethylene glycol (PEG) to improve antigenic DNA somatic reaction and structure and activity were integrated into PLGA nanomicrospheres (NIM) for DNA delivery.…”

Section: Cationic Polymer-based Ph-sensitive Polymericmentioning

confidence: 99%

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Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

Mao

Luo

et al. 2023

ACS Nano

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The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment of cancer and a variety of infectious diseases due to their superior biocompatibility, lower toxicity and reduced immunogenicity. Particularly, stimuli-responsive polymeric nanocarriers show great promise for delivering antigens and adjuvants to targeted immune cells, preventing antigen degradation and clearance, and increasing the uptake of specific antigen-presenting cells, thereby sustaining adaptive immune responses and improving immunotherapy for certain diseases. In this review, the most recent advances in the utilization of stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications are presented. These sophisticated polymeric nanovaccines with diverse functions, aimed at therapeutic administration for disease prevention and immunotherapy, are further classified into several active domains, including pH, temperature, redox, light and ultrasound-sensitive intelligent nanodelivery systems. Finally, the potential strategies for the future design of multifunctional next-generation polymeric nanovaccines by integrating materials science with biological interface are proposed.

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Section: Ph-sensitive Polymeric Nanovaccinesmentioning

confidence: 99%

Section: Cationic Polymer-based Ph-sensitive Polymericmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

Mao

Luo

et al. 2023

ACS Nano

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“…4A–E). 63 Polysaccharides from CHMs, such as Angelica sinensis polysaccharide, 64–66 Chinese yam polysaccharide 67,68 and Ramulus mori polysaccharide, 69 can also be developed into polymer nanoparticles to improve the immune response. Angelica sinensis polysaccharide (ASP)-loaded PLGA nanoparticles are encapsulated by polyethylenimine (PEI) to form the ASP–PLGA–PEI system, which is subsequently used to activate macrophages and thus increase antigen uptake by macrophages.…”

Section: Engineered Nanostructures Of Chmsmentioning

confidence: 99%

Nanostructures in Chinese herbal medicines (CHMs) for potential therapy

Zhang

Wang

et al. 2023

Nanoscale Horiz.

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“…Xu et al . designed pH-sensitive PLGA NPs loaded with astragalus polysaccharide (APS) as an adjuvant system to enhance immune responses [ 165 ]. Their results revealed that pH-responsive APSPs considerably increased macrophage phagocytosis capacity and markedly increased MHC-II, CD80, and CD86 expression [ 165 ].…”

Section: Introductionmentioning

confidence: 99%

“…When compared to APS alone, both OVA-loaded NPs were able to dramatically increase the proliferation, differentiation, and maturity of mouse spleen lymphocytes and dendritic cells, respectively, as well as trigger stronger Th1-biased immune responses. NPs dramatically increased the production of TNF-α, IL-4, IL-6, IFN-γ, and antigen-specific IgG antibody responses [ 165 ].…”

Section: Introductionmentioning

confidence: 99%

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Sun,

Zhao,

et al. 2024

J Nanobiotechnol

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Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role in preventing illness by preparing the body's adaptive and innate immune responses to combat diseases. As our understanding of malignancies and their connection to the immune system improves, there has been a growing interest in priming the immune system to fight malignancies more effectively and comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which has been shown to potentiate immune responses as vaccines and/or adjuvants. In this review, we comprehensively summarized the immunological mechanisms of cancer vaccines while focusing specifically on the recent applications of various types of nanoparticles in the field of cancer immunotherapy. By exploring these recent breakthroughs, we hope to identify significant challenges and obstacles in making nanoparticle-based vaccines and adjuvants feasible for clinical application. This review serves to assess recent breakthroughs in nanoparticle-based cancer vaccinations and shed light on their prospects and potential barriers. By doing so, we aim to inspire future immunotherapies for cancer that harness the potential of nanotechnology to deliver more effective and targeted treatments. Graphical abstract

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pH-responsive Astragalus polysaccharide-loaded PLGA nanoparticles as an adjuvant system to improve immune responses

Cited by 6 publications

References 30 publications

Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy

Nanostructures in Chinese herbal medicines (CHMs) for potential therapy

The quest for nanoparticle-powered vaccines in cancer immunotherapy

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