1996
DOI: 10.1016/0301-0082(95)00039-9
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pH regulation and proton signalling by glial cells

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Cited by 281 publications
(287 citation statements)
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“…3E). The absence of cytosolic acidification by low levels of ammonium is consistent with the higher pH and lower buffering capacity of the mitochondrial matrix relative to the cytosol (34), compounded by muffling from the high levels of cytosolic bicarbonate and carbonic anhydrase present in astrocytic cytosol (35). The uptake of pyruvate by mitochondria is mediated by the mitochondrial pyruvate carrier (MPC), which is an H + -pyruvate cotransporter (36,37).…”
Section: Resultsmentioning
confidence: 74%
“…3E). The absence of cytosolic acidification by low levels of ammonium is consistent with the higher pH and lower buffering capacity of the mitochondrial matrix relative to the cytosol (34), compounded by muffling from the high levels of cytosolic bicarbonate and carbonic anhydrase present in astrocytic cytosol (35). The uptake of pyruvate by mitochondria is mediated by the mitochondrial pyruvate carrier (MPC), which is an H + -pyruvate cotransporter (36,37).…”
Section: Resultsmentioning
confidence: 74%
“…Several types of transistors that can gate and amplify ionic currents have been described in the literature [18][19][20][21][22] . Diodes are attractive due to their rectification property and they can be used in simple logic gate 45 circuits and also as the addressing element in cross-point matrix systems. Several different types of ion diodes have previously been reported, based on either nanofluidic channels [23][24][25] , hydrogels [26][27][28][29] , or BMs [30][31][32] .…”
Section: Introductionmentioning
confidence: 99%
“…During ischemia, extracellular pH falls, and the acidosis contributes to neuronal injury (13)(14)(15). Seizures and hyperglycemia can also generate an acidic extracellular environment that contributes to neuronal injury (16,17). Prolonged exposure to an acidic environment may also alter the number of ASIC channels in central neurons (18), perhaps altering their responsiveness to acidosis.…”
mentioning
confidence: 99%