pH/redox sensitive nanoparticles with platinum(iv) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer

Abstract

pH/redox sensitive, dual drug loaded nanoparticles were prepared from poly(ethylene glycol)-block-poly(l-lysine) (PEG-b-PLL) for improving cancer therapy.

Recent Advances in the Chemistry of Metal Carbamates

“…Following a different approach, the incorporation of a maleimide fragment enabled specific interactions with proteins (e.g., addition to thiol residues) for compounds showing a promising anticancer activity in vivo [261,268,369]. The conjugation with suitable targeting groups, to enhance the pharmacological performance, can be achieved via modification of either the axial carboxylato co-ligand [367,370] or the carbamato ligand itself [272,371,372]. Remarkably, all of these Pt(IV) complexes are stable for several hours or even days in physiological aqueous solutions [260,261,263,272].…”

“…Platinum(IV) carbamato complexes with simple organic substituents on the nitrogen revealed a considerable cytotoxicity against various cancer cell lines, comparable or superior to that of the reference Pt(II) drug cisplatin [ 260 , 262 , 263 ]. A C 16 aliphatic chain (fatty acid-like) was introduced through the carbamato ligand to enhance cellular uptake [ 263 , 264 , 266 , 366 , 367 , 368 ]. Following a different approach, the incorporation of a maleimide fragment enabled specific interactions with proteins (e.g., addition to thiol residues) for compounds showing a promising anticancer activity in vivo [ 261 , 268 , 369 ].…”

Supramolecular nanomotors with “pH taxis” for active drug delivery in the tumor microenvironment

“…44 Previously, pH/redox sensitive DOX loaded nanoparticles were prepared from poly(ethylene glycol)-block-poly(L-lysine) (PEG-b-PLL) for improving cancer therapy and similar results were observed under acidic conditions. 45 However, the system was based on passive delivery. In here we expect the use of CaCO 3 to both power and actuate stomatocytes to actively target tumor tissues and cells due to slightly acidic pH, and also for active delivery of drugs due to the ease of entrapment, thereby increasing the bioavailability and efficacy.…”

Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives

“…The nanoparticle could be used as a nanocarrier further to encapsulate other drugs such as DOX for combined chemotherapy. The pH/Redox sensitive, dual drug-loaded nanoparticles were prepared from PEG- b -PLL to improve cancer therapy [ 234 ]. Platinum (IV) and cis -aconitic anhydride doxorubicin (CAD) were anchored to residual amine groups of PLL to form polymer prodrug conjugates, which then self-assembled into nanoparticles with hydrophobic platinum (IV) prodrug and CAD as the core.…”