pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy

Zhao, Yanbin; He, Peng; Yao, Junyan; Li, Mei; Wang, Bin; Li, Han; Huang, Zhihai; Guo, Chunhuan; Bai, Jing; Xue, Feng; Yu, Cong; Cai, Wei; Chu, Paul K.; Chu, Chenglin

doi:10.1016/j.biomaterials.2023.122237

Cited by 29 publications

(7 citation statements)

References 93 publications

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“…In order to evaluate the osteogenic property of different samples, the alkaline phosphatase (ALP) which represented an early marker of osteogenic differentiation was assessed. 36 As shown in Figure 4(b). both the AH-Ti and AH-Ti/Ag1 showed higher ALP activity (p < .01) than AH-Ti/ Ag5 after 4/7 days of osteogenic induction.…”

Section: Osteogenic Differentiation Evaluationmentioning

confidence: 77%

Fabrication and evaluation of silver modified micro/nano structured titanium implant

Huang,

Wang,

Yao

et al. 2024

J Biomater Appl

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In order to enhance the antibacterial property of titanium implant without inducing obvious cytotoxicity, the combination of Ag nanolayer and micro/nano surface structure was conducted by magnetron sputtering and hot-alkali treatment in this study. A series of specimens (AH-Ti, AH-Ti/Ag0.25, AH-Ti/Ag1, AH-Ti/Ag2, and AH-Ti/Ag5) were prepared with different sputtering durations (0 min, 0.25 min, 1 min, 2 min, 5 min), respectively, all realizing long-term release of Ag+. In vitro experiments indicated that AH-Ti/Ag1 group possessed good cytocompatibility, nice osteogenic ability, and excellent antibacterial efficiency as well. In addition, AH-Ti/Ag0.25 showed good biocompatibility, while the reduction of S.aureus (78.5%) was not enough compared with AH-Ti/Ag1. Although the AH-Ti/Ag2 and AH-Ti/Ag5 group showed superior antibacterial activity, their obvious cytotoxicity caused low ALP and mineralization level. Therefore, the design of suitable Ag nanolayer coating combined with micro/nano surface structure (AH-Ti/Ag1) might be a promising strategy to enhance osteogenic property and maintain excellent antibacterial ability at the same time.

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Section: Osteogenic Differentiation Evaluationmentioning

confidence: 77%

Fabrication and evaluation of silver modified micro/nano structured titanium implant

Huang,

Wang,

Yao

et al. 2024

J Biomater Appl

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“…A modified Stöber method was used to synthesize mesoporous silica nanoparticles (MSNs). 35 Briefly, F127 (1 g mL −1 ) and CTAB (4.1 g mL −1 ) were mixed in an alcohol–water mixture (v/v = 86.2 mL/192 mL), and NH 3 (aq, 22.4 mL) was then added. TEOS (3.86 mL) was quickly injected into this blend and stirred for another 15 hours.…”

Section: Methodsmentioning

confidence: 99%

NIR-responsive magnesium phosphate cement loaded with simvastatin-nanoparticles with biocompatibility and osteogenesis ability

Wang,

Zhao,

et al. 2024

RSC Adv.

Self Cite

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“…A self‐repairing polymer coating technique is utilized to produce these coatings, involving the use of hyaluronic acid (HA) and poly(ethylene imine) (bPEI) in a spin‐assisted layer‐by‐layer (SLbL) assembly process on magnesium alloys. [ 169 ] In a similar study, a self‐repairing polymer coating was created on magnesium alloy using spin‐coating layer‐by‐layer assembly, along with a drug delivery nanoplatform that responds to stimuli. The nanocontainers, based on hollow mesoporous silica nanoparticles encapsulating simvastatin, were functionalized with dopamine and polycaprolactone diacrylate.…”

Section: Self‐healing Biomaterials In Bone Tumor Therapy and Regenera...mentioning

confidence: 99%

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Wang,

Zhang,

Qiang

et al. 2024

Adv Healthcare Materials

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Surgical resection of bone tumors is the primary approach employed in the treatment of bone cancer. Simultaneously, perioperative interventions, particularly postoperative adjuvant anticancer strategies, play a crucial role in achieving satisfactory therapeutic outcomes. However, the occurrence of postoperative bone tumor recurrence, metastasis, extensive bone defects, and infection are significant risks that can result in unfavorable prognoses or even treatment failure. In recent years, there has been significant progress in the development of biomaterials, leading to the emergence of new treatment options for bone tumor therapy and bone regeneration. This progress report aims to comprehensively analyze the strategic development of unique therapeutic biomaterials with inherent healing properties and bioactive capabilities for bone tissue regeneration. These composite biomaterials, classified into metallic, inorganic non‐metallic, and organic types, are thoroughly investigated for their responses to external stimuli such as light or magnetic fields, internal interventions including chemotherapy or catalytic therapy, and combination therapy, as well as their role in bone regeneration. Additionally, we provide an overview of self‐healing materials for osteogenesis and explore their potential applications in combating osteosarcoma and promoting bone formation. Furthermore, we address the safety concerns of integrated materials and current limitations, while also discussing the challenges and future prospects.This article is protected by copyright. All rights reserved

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pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy

Cited by 29 publications

References 93 publications

Fabrication and evaluation of silver modified micro/nano structured titanium implant

Fabrication and evaluation of silver modified micro/nano structured titanium implant

NIR-responsive magnesium phosphate cement loaded with simvastatin-nanoparticles with biocompatibility and osteogenesis ability

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

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