pH-induced variations in the TK1 gene model

Massonneau, Julien; Lacombe-Burgoyne, Chloë; Boissonneault, Guylain

doi:10.1016/j.mrgentox.2019.503128

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…Strikingly, the ability of CIRTs to avoid the NMD pathway depends on the cellular micro-environmental conditions such as hypoxia, infection, and the lack of nutrients (Karam et al, 2013;Hug et al, 2015;Li et al, 2017;Nasif et al, 2018). Those conditions of cellular microenvironment are well-established hallmarks for a wide range of inflammatory-based diseases ranging from cancer to neuropathies, which emphasize the significance of IR in pathological states (Brady et al, 2017;Farina et al, 2020;Massonneau et al, 2020;Tan et al, 2020). The survival of IR-mRNAs from the cellular regulatory control becomes more apparent due to the advancement in IR-mRNA detection methods such as deep sequencing (Zheng et al, 2020).…”

Section: The Fate Of Intron Containing Transcriptsmentioning

confidence: 99%

Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts

Khalifah,

Alghamdi,

Alhasan

2023

Front. Bioeng. Biotechnol.

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Human transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer disease (AD), Huntington disease (HD), myelodysplastic syndromes (MDS). Intron retention (IR) is a major inducer of spliceopathies where two or more introns remain in the final mature mRNA and account for many intronic expansion diseases. Potential removal of such introns for therapeutic purposes can be feasible when utilizing bioinformatics, catalytic RNAs, and nano-drug delivery systems. Overcoming delivery challenges of catalytic RNAs was discussed in this review as a future perspective highlighting the significance of utilizing synthetic biology in addition to high throughput deep sequencing and computational approaches for the treatment of mis-spliced transcripts.

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Section: The Fate Of Intron Containing Transcriptsmentioning

confidence: 99%

Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts

Khalifah,

Alghamdi,

Alhasan

2023

Front. Bioeng. Biotechnol.

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“…Mutated versions of genes known as alleles are created when a small-scale variation occurs in DNA bases' gene sequence. These variations in gene sequence can prevent the proteins from working properly [9]- [11]. Unable to perform the tasks can lead to change in a cell or an organ and leads to a disease.…”

Section: Introductionmentioning

confidence: 99%

An FPGA-Based Accelerated Mutation Detection System for the Tumor Suppressor Gene

et al. 2021

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This paper proposes a novel fast mutation detection system that looks for mutations in the tumor suppressor gene, also known as TP53. Mutations are modifications in the nucleotide sequences of the human genome and may be caused by various factors, such as exposure to radiation, sunlight, smoking and replication errors. Mutations in TP53 are the most common cause of cancer and early detection may prevent cancer from happening. The proposed system utilizes the high matching speed of a logic-based contentaddressable memory (CAM) for mutation detection along with a hamming distance calculator that specifies the exact location of the mutation. The proposed system implementation is carried on a Xilinx Virtex®-7 field-programmable gate array (FPGA) and demonstrates a low match time of 0.18 µs, which is much faster compared to the state-of-the-art systems.

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pH-induced variations in the TK1 gene model

Cited by 2 publications

References 37 publications

Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts

Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts

An FPGA-Based Accelerated Mutation Detection System for the Tumor Suppressor Gene

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