pH-Driven Reversible Assembly and Disassembly of Colloidal Gold Nanoparticles

Liu, Yun; Fu, Weihua; Xu, Zhongsheng; Zhang, Liang; Sun, Tao; Du, Mengmeng; Kang, Xun; Xiao, Shilin; Zhou, Chunyu; Gong, Mingfu; Zhang, Dong

doi:10.3389/fchem.2021.675491

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…The position of the band is in good agreement with the results of other authors, who also attribute this band to irregular agglomerates/clusters/"oligomers" of gold nanoparticles. [32][33][34][35][36][37][38][39][40] Most likely, so clusters consist of a few particles, since their mean hydrodynamic diameter will typically not exceed 200 nm. At t > 20 min also an absorption band at 10 500 cm −1 (ca.…”

Section: Gnp Agglomerates In Acidic Suspensionsmentioning

confidence: 99%

Agglomeration compaction promotes corrosion of gold nanoparticles

Snopok,

Nizamov,

Snopok

et al. 2024

Nanoscale Adv.

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Section: Gnp Agglomerates In Acidic Suspensionsmentioning

confidence: 99%

Agglomeration compaction promotes corrosion of gold nanoparticles

Snopok,

Nizamov,

Snopok

et al. 2024

Nanoscale Adv.

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“…Slight variations in the maximum absorbance peaks were observed in both AgNPs and AuNPs which also con rmed that the nanoparticles had not undergone any changes in shape or structure after conjugation. The measurements were carried out utilizing an Agilent Technologies Instrument Carry 5000 UV-Vis NIR spectrophotometer [50].…”

Section: Visible Spectral Analysismentioning

confidence: 99%

Computational identification of PDL1 inhibitors and their cytotoxic effects with silver and gold nanoparticles

Ali,

Aziz

2024

Preprint

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Background Immunotherapy is a promising treatment for cancer that aims to boost the immune system's response to cancer cells. This can be achieved by blocking PD1(Programmed cell death 1)/PDL1(Programmed death-ligand 1), which activates T cells. In this work, the aim was to find high-affinity drugs against PDL1 using computational tools and conjugate them with nanoparticles. The cytotoxic activity of the drug-conjugated nanoparticles was then tested. Methods The screening of one hundred thousand drugs from the ZINC database and FDA-approved drugs was done computationally. The physicochemical properties and toxicity of the drugs were analyzed using SwissADME and ProTox-II respectively. AgNPs and AuNPs were synthesized using extracts of Catharanthus roseus flowers and Juglans regia shells, respectively. The characterization of AgNPs and AuNPs was performed using UV-Vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR). Their conjugation with the drugs Irinotecan, Imatinib, and Methotrexate was also confirmed using UV-Vis, FTIR, and Dynamic light scattering (DLS). Results The top screened drugs were ZINC1098661 and three FDA-approved drugs (Irinotecan, Imatinib, and Methotrexate). Docking studies revealed that Irinotecan had the highest binding affinity towards PDL1 when conjugated with silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). The Irinotecan-PDL1 complex was confirmed as the most stable through molecular dynamics simulations. The result of methylthiazol tetrazolium (MTT) assay showed that conjugated AgNPs and AuNPs with Irinotecan had a high toxic effect on A549 cancer cell line than Imatinib conjugated with AgNPs and AuNPs. Conclusion: This study provides a promising avenue for further investigation and development of nanoparticle-drug conjugates as a potential cancer immunotherapy strategy.

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“…The systems by pH‐induced reversible aggregation and dispersion of NPs are usually constructed by introducing pH‐responsive ligands onto NP surfaces. Some common ligands, such as glutathione, [ 75 ] GCPZ, [ 51 ] and 3‐aminopropyltriethoxysilane, [ 90 ] can trigger intermolecular interactions in a specific pH range (e.g., electrostatic interactions, hydrogen bonding). Figure 4d shows the reversible aggregation of Au NPs modified by the pH‐responsive GCPZ.…”

Section: Nano/microscale Materials By Stimuli‐responsive Np Aggregationmentioning

confidence: 99%

From Nanoscopic to Macroscopic Materials by Stimuli‐Responsive Nanoparticle Aggregation

et al. 2023

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color changes to adapt to different environments by tuning the spacing of guanine nanocrystals; [12] salmon can find their way by using magnetite NPs on their forehead in response to Earth's magnetic field. [13,14] Inspired by nature, researchers and engineers have devoted intensive efforts to control the aggregation of "smart" NPs for constructing superstructures by regulating external stimuli. Generally, these "smart" NPs are obtained through two main approaches. One is to assemble functional molecules to NPs (nanogels, [15] proteins, [16] etc.) by covalent/noncovalent interactions. However, little attention has been paid on their aggregation caused by external stimuli. The other most popular method is to decorate functional ligands (small molecules, supermolecules, polymers, etc.) onto the surfaces of NPs (inorganic metal, metal oxide, silica, etc.). These ligands can provide a variety of interactions (e.g., hydrophobic interactions, hydrogen bonding, electrostatic interactions, and host-guest interactions) to regulate NP aggregation under different external stimuli. The combination of smart NPs and external stimuli provides an amazing and promising route to create functional materials or devices with highly tunable unique properties.For many decades, stimuli-responsive NP aggregation at micro or macroscale has aroused great interest and broad explorations for its potential applications in biomedical engineering, [17] robot technology, [18] and energy conversion. [19] Since Mirkin et al. reported a DNA-based method to assemble NPs into macroscopic aggregates by thermal variation in 1996, [20] many intelligent multiscale assembly of smart NPs from nano/ microscopic aggregates to macroscopic materials have been spatio-temporally realized in a remote way by various external stimuli such as temperature, pH, light, electric, and magnetic fields. Several typical NP superstructures have been created at nano/microscale, such as disordered aggregates, [21] ordered superlattices, [22] structural droplets, [23] and colloidosomes. [24] To obtain large macroscopic materials is still a great challenge, notwithstanding a few successful examples, centimeterscale-ordered bulk solids [25] and switchable liquid-solid bulk materials. [26] Some excellent reviews have summarized the NP assembly methods and strategies, such as evaporation-induced NP assembly, [27,28] polymer-guided NP assembly, [29,30] biomoleculemediated NP assembly, [31,32] etc. In this review, we focus on the recent advances of stimuli-responsive NP aggregation systems that have been developed to construct some typical functional Stimuli-responsive nanoparticle (NP) aggregation plays an increasingly important role in regulating NP assembly into microscopic superstructures, macroscopic 2D, and 3D functional materials. Diverse external stimuli are widely used to adjust the aggregation of responsive NPs, such as light, temperature, pH, electric, and magnetic fields. Many unique structures based on responsive NPs are constructed including disordered aggregates, order...

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pH-Driven Reversible Assembly and Disassembly of Colloidal Gold Nanoparticles

Cited by 5 publications

References 26 publications

Agglomeration compaction promotes corrosion of gold nanoparticles

Agglomeration compaction promotes corrosion of gold nanoparticles

Computational identification of PDL1 inhibitors and their cytotoxic effects with silver and gold nanoparticles

From Nanoscopic to Macroscopic Materials by Stimuli‐Responsive Nanoparticle Aggregation

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