pH-dependent oiling-out during the polymorph transformation of disodium guanosine 5′-monophosphate

Abstract

Oiling-out occurs frequently in industrial crystallization, and strongly influences the morphology and quality of crystals. In this study, the influence of oiling-out with higher pH during the polymorph transformation of...

Liquid–liquid phase separation and crystallization of aspirin polymorphs from a water–acetonitrile mixed solvent medium through a swift cooling process

“…Measurement of the pH plays a vital role in the pharmaceutical industry for controlling the drug quality, especially for identifying any chemical changes during the processing and for drug stability. 43 Fig. 4 describes the pH variation with respect to the different binary mixed compositions of the solvents.…”

Production of functional spherical particles with porous hollow structures in water via oiling-out directional agglomeration

“…[33][34][35] In earlier studies, the universality and complexity of oiling-out brought great difficulties to the design and control of the crystallization process. [36][37][38][39][40] As more cases have been reported, researchers have found that under specific conditions, high enrichment of solutes in the oil droplets makes oiling-out closer to the "aqueous melt" state, which makes obtaining crystal structures that are difficult to prepare by conventional means easier. 31 Meanwhile, the oil droplet will become a natural spherical confined space due to agitation, and spherical particles with a variety of micro/nanostructures can be produced in water by reasonably adjusting the process parameters.…”