pH dependent degradation properties of lactide based 3D microchamber arrays for sustained cargo release

Liu, Yuechi; Gai, Meiyu; Sukvanitvichai, Dusita; Frueh, Johannes; Sukhorukov, Gleb B.

doi:10.1016/j.colsurfb.2020.110826

Cited by 13 publications

(8 citation statements)

References 38 publications

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“…Despite the burst release during the initial 60 min, the total releasing period for the MICL was prolonged to ∼6 h with the higher released amount. Although drug release times have been longer in previous studies, contact lenses should not be worn for more than 8 h per day for tolerance and comfort. ,− Thus, the MICL not only showed better drug loading capacity but also revealed long-term drug release ability, which indicated the comparable sustainable release ability of small molecules with the previously reported polylactic acid microchamber Figure D shows the effects of different buffer media on the DSP release.…”

Section: Resultsmentioning

confidence: 80%

Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release

Chu

Xue

Shao

et al. 2021

ACS Appl. Bio Mater.

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As a noninvasive eye disease detection and drug delivery device, contact lenses can improve eye bioavailability and enable continuous drug delivery. In order to monitor the release of drugs in real time, molecularly imprinted contact lenses (MICLs) based on photonic crystals (PCs) were prepared for the treatment of diabetes-related diseases. The specific adsorption of molecularly imprinted polymers on dexamethasone sodium phosphate (DSP) increased the drug loading and optimized the drug release behavior. At the same time, the drug release ensures the rapid color report during the loading and releasing of drugs due to the volume and refractive index change of the hydrogel matrix. The continuous and slow release of DSP by MICLs in artificial tears was successfully monitored through structural color changes, and the cytotoxicity test results showed that the MICL had good biocompatibility. Therefore, MICLs with a PC structure color have great biomedical potentiality in the future.

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Section: Resultsmentioning

confidence: 80%

Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release

Chu

Xue

Shao

et al. 2021

ACS Appl. Bio Mater.

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“…Thus, the obtained systems enable a prolonged release over time, while protecting the carried cargo from the external aqueous environment. Previously, the stimuli-responsive release from microchambers has been shown to utilize different approaches including near-infrared laser, 53 pH, 54 and ultrasound. The microbubbles in the lumen of microchambers make it possible to break it using ultrasound treatment due to a significant difference in ultrasound impedance between inside and outside of the microchambers.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Kudryavtseva

Boi

Read

et al. 2021

ACS Appl. Mater. Interfaces

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This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core−shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small watersoluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 μm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size.

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“…They are thin polymer films (from 1 to several microns) with many ordered, hermetically sealed microcontainers filled with cargo [ 17 , 18 ]. They can be easily manufactured from biocompatible polymers (polylactic acid (PLA) [ 19 , 20 ], poly (lactic-co-glycolic acid) (PLGA) [ 16 , 21 ], polycaprolactone (PCL) [ 16 ], and their copolymers). Microchamber arrays are formed by pressing together flat and embossed hydrophobic polymer films filled with the drug under slight heating (55–80 °C for 5–30 s).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation

et al. 2022

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Bladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery. Balloon dilation is a minimally invasive alternative to the surgical dissection of tissues; however, it significantly reduces the patient’s quality of life. Additional local anti-inflammatory treatment may reduce the number of procedures requested and increase the attractiveness of this therapeutic strategy. Here, we report about an ultrathin biocompatible coating based on polylactic acid for Foley catheter balloons that can provide localized release of Prednol-L in the range of 56–99 µg in the BNC zone under conventional diagnostic ultrasound exposure. Note that the exposure of a transrectal probe with a conventional gray-scale ultrasound regimen with and without shear wave elastography (SWE) was comparably effective for Prednol-L release from the coating surface of a Foley catheter balloon. This strategy does not require additional manipulations by clinicians. The trigger for the drug release is the ultrasound exposure, which is applied for visualization of the balloon’s location during the dilation process. In vivo experiments demonstrated the absence of negative effects of the usage of a coated Foley catheter for balloon dilation of the bladder neck and urethra.

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pH dependent degradation properties of lactide based 3D microchamber arrays for sustained cargo release

Cited by 13 publications

References 38 publications

Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release

Photonic Crystal-Embedded Molecularly Imprinted Contact Lenses for Controlled Drug Release

Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery

Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation

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