pH-Dependent conformational stability of SpeB from
            <i>Thermus thermophilus</i>
            HB8: insights from molecular dynamics simulation

Veerapandian, Malaisamy; Hemavathy, Nagarajan; Karthika, Alagesan; Manikandan, Jayaraman; Vetrivel, Umashankar; Jeyakanthan, Jeyaraman

doi:10.1080/08927022.2023.2281987

Cited by 1 publication

(2 citation statements)

References 40 publications

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“…Additionally, a recent study reported that the use of fipronil, a broad-spectrum insecticide, harms gut health, potentially driving PD. The protein diaminopimelate converter (DapF) found in Lactobacillus and tyrosine carboxylase (TDC) from Enterococcus help bacteria maintain normal function and produce metabolites . Simulations of their interaction with Fipronil sulfone (FS) at 92 mg/L for 100 ns showed that FS induced conformational changes in DapF and TDC.…”

Section: Pesticide-induced Gut Dysbiosismentioning

confidence: 99%

“…The protein diaminopimelate converter (DapF) found in Lactobacillus and tyrosine carboxylase (TDC) from Enterococcus help bacteria maintain normal function and produce metabolites. 64 Simulations of their interaction with Fipronil sulfone (FS) at 92 mg/L for 100 ns showed that FS induced conformational changes in DapF and TDC. These changes could inhibit bacterial function, reduce metabolite production, and potentially influence PD.…”

Section: Pesticide-induced Gut Dysbiosismentioning

confidence: 99%

See 1 more Smart Citation

Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease

Ghosh,

Sinha,

Sil

2024

Chem. Res. Toxicol.

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Parkinson’s disease (PD) affects more people worldwide than just aging alone can explain. This is likely due to environmental influences, genetic makeup, and changes in daily habits. The disease develops in a complex way, with movement problems caused by Lewy bodies and the loss of dopamine-producing neurons. Some research suggests Lewy bodies might start in the gut, hinting at a connection between these structures and gut health in PD patients. These patients often have different gut bacteria and metabolites. Pesticides are known to increase the risk of PD, with evidence showing they harm more than just dopamine neurons. Long-term exposure to pesticides in food might affect the gut barrier, gut bacteria, and the blood–brain barrier, but the exact link is still unknown. This review looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria. We have examined the interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.

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Section: Pesticide-induced Gut Dysbiosismentioning

confidence: 99%

Section: Pesticide-induced Gut Dysbiosismentioning

confidence: 99%