pH-Dependent Behavior of Novel Gellan Beads Loaded with Naproxen

Osmałek, Tomasz; Froelich, Anna; Milanowski, Bartłomiej; Bialas, M; Hyla, Kinga; Szybowicz, Mirosław

doi:10.2174/1567201814666170303120936

Cited by 19 publications

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“…Without the surfactant, NPX formed agglomerates which resulted in clogging of the encapsulator. Moreover, as we have shown in our previous work, 61 Tween V R 80 can have an influence on the beads formation process and their shape. Based on the visual observations, it was concluded that the shape of the wet beads was similar to spherical or slightly oval ( Figure 1).…”

Section: Morphology Of the Beadsmentioning

confidence: 53%

“…Many different factors including concentration and type of the polymer, physicochemical properties of the drug or additives, as well as the type of the cross-linking ions, can have an impact of the properties of the beads obtained by ionotropic gelation. 37,39,61,74 Moreover, the parameters of the final product can be affected by the conditions during the production process i.e. temperature of the drug-polymer mixture, instillation flow rate, diameter of the tubes and the needle, height of instillation, mixing speed of the gelling medium or curing time.…”

Section: Resultsmentioning

confidence: 99%

“…temperature of the drug-polymer mixture, instillation flow rate, diameter of the tubes and the needle, height of instillation, mixing speed of the gelling medium or curing time. 61,75 As can be concluded from the experimental part, the NPX-loaded beads were produced under constant conditions and the main goal was to investigate the influence of the polymer composition on the properties of the beads. During preparation of polymer-drug mixtures, it was necessary to add Tween V R 80 to achieve the homogenous suspension.…”

Section: Morphology Of the Beadsmentioning

confidence: 99%

“…The DSC curve of NPX shows one sharp endothermic peak with an onset at 155.7 C and an enthalpy of fusion DH NPX ¼ 138.0 J g À1 due to melting as previously reported by us. 61 The summary of DSC data is shown in Table 4. The melting peak of NPX in the formulation is clearly observed, confirming its presence in a crystalline form in the beads; however, some dislocations in the melting temperature as well as in the enthalpy of fusion in all the formulations are seen.…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

“…As it was shown in our previous studies, the pH-dependent behavior of NPX-loaded gellan beads strictly corresponded to the amount of the polymer and drug used during production. 61 The aim of the present work was to investigate whether the addition of various naturally derived polymers to gellan influence the properties of the beads. For the investigation, we have prepared the beads with gellan blended with six naturally derived polymers.…”

Section: Introductionmentioning

confidence: 99%

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Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior

et al. 2018

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Aims After oral administration, naproxen generates several side-effects related to stomach malfunction. Undoubtedly, the enteric dosage forms with naproxen can be considered as safer. Moreover, since it has been evidenced that development and growth of colorectal cancer is related to the presence of cyclooxygenase, naproxen is investigated in terms of the tumor prevention. The aim of the present work was to formulate and evaluate the properties of novel naproxen-loaded macrobeads, made on the basis of low-acyl gellan gum and its blends with carrageenans, guar gum, cellulose sulfate, and dextran sulfates. Method Seven formulations were prepared by ionotropic gelation. The morphology of the dried beads was evaluated by scanning electron microscopy. The next step focused on Raman spectroscopy and thermal analysis of naproxen, polymers, and the beads. Next, the swelling behavior was examined in three acceptor fluids at pH = 1.2; 4.5, and 7.4. The beads were evaluated regarding naproxen content and encapsulation efficiency. The last stage of the work concerned the drug release studies. Results Addition of any other polysaccharide than gellan resulted in flattening of the beads upon drying. Differential scanning calorimetry confirmed the crystalline form of naproxen. Raman spectra showed that no apparent interactions occurred. In the acidic environment, all the beads revealed the tendency to absorb water. The beads swelled to the greatest extent at pH = 4.5. Naproxen was released from the beads at a varied rate. At pH = 7.4, the most prolonged release was observed for the beads containing carrageenans. Conclusions We have proved that blending of gellan with various polysaccharides can change the pH-dependent properties of the beads loaded with naproxen. We believe that the information enclosed in the paper will be of particular importance regarding the development and characteristics of novel oral dosage forms based on natural polymers.

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Section: Morphology Of the Beadsmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Morphology Of the Beadsmentioning

confidence: 99%

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior

et al. 2018

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Accelerating the remodeling of collagen in cutaneous full‐thickness wound using FIR soldering technology with bio‐targeting nanocomposites hydrogel

Chen,

Wang

et al. 2024

Journal of Biophotonics

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A novel composite wound dressing hydrogel by incorporating single‐walled carbon nanotubes and indocyanine green into a dual‐crosslinked hydrogel through Schiff base reaction was developed. The objective was to prevent wound infection and enhance the thermal effect induced by laser energy. The hydrogel matrix was constructed using oxidized gelatin, pre‐crosslinked with calcium ions, along with carboxymethyl chitosan, crosslinked via Schiff base reaction. Optimization of the blank hydrogel's gelation time, swelling index, degradation rate, and mechanical properties was achieved by adding 0.1% SWCNT and 0.1% ICG. Among them, the SWCNT‐loaded hydrogel BCG‐SWCNT exhibited superior performance overall: a gelation time of 102 s; a swelling index above 30 after equilibrium swelling; a degradation rate of 100.5% on the seventh day; and a compressive modulus of 8.8 KPa. It displayed significant inhibition against methicillin‐resistant Staphylococcus aureus infection in wounds. When combined with laser energy usage, the composite hydrogel demonstrated excellent pro‐healing activity in rats.

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Exopolysaccharides in Drug Delivery Systems

Razzaghi

Navvabi

Homaee

et al. 2021

Microbial Exopolysaccharides as Novel and Significant Biomaterials

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pH-Dependent Behavior of Novel Gellan Beads Loaded with Naproxen

Abstract: In general, it can be stated that gellan macro beads may be regarded as suitable for site specific delivery of NPX to the colon. However, these simple to obtain beads can be potentially used as carriers for many different drugs whenever it is necessary to omit the stomach.

Cited by 19 publications

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Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior

Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior

Accelerating the remodeling of collagen in cutaneous full‐thickness wound using FIR soldering technology with bio‐targeting nanocomposites hydrogel

Exopolysaccharides in Drug Delivery Systems

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