pH-Controlled multiple-drug delivery by a novel antibacterial nanocomposite for combination therapy

Zeynabad, Fatemeh Bazmi; Salehi, Roya; Alizadeh, Effat; Kafil, Hossein Samadi; Hassanzadeh, Azad Mohammad; Mahkam, Mehrdad

doi:10.1039/c5ra22784d

Cited by 49 publications

(17 citation statements)

References 32 publications

(44 reference statements)

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“…A hard segment in pure polyurethane was responsible for delayed drug release, whereas the self-assembled structure and graphene moieties acted as a barrier for the diffusion of loaded drugs in nanohybrids. Several other polymer nanoparticle hybrid systems have been reported as sustained release systems for cancer therapy using different drugs, such as DOX, 5-FU, and MTX 145 – 149 . The dual-administration of DOX with MTX had higher cytotoxicity towards T47D breast cancer cells than free dual drug forms.…”

Section: Materials and Strategies Used In Cancer Therapymentioning

confidence: 99%

Controlled drug delivery vehicles for cancer treatment and their performance

Senapati

Mahanta

Kumar

et al. 2018

Sig Transduct Target Ther

1,591

935

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Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

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Section: Materials and Strategies Used In Cancer Therapymentioning

confidence: 99%

Controlled drug delivery vehicles for cancer treatment and their performance

Senapati

Mahanta

Kumar

et al. 2018

Sig Transduct Target Ther

1,591

935

View full text Add to dashboard Cite

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“…It is therefore possible to combine delivery of anticancer and antibacterial drugs. Zeynabad et al [35] proposed a multifunctional drug delivery system based on cationic silica-based polymer-clay nanocomposite for such combined therapy. The nanocomposite (NC) was loaded with two anticancer and one antibacterial agent, ciprofloxacin (CIP).…”

Section: Ph-responsive Nanomaterialsmentioning

confidence: 99%

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

Tallet

Gribova

Ploux

et al. 2020

Adv Healthcare Materials

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To fight against antibiotic‐resistant bacteria adhering and developing on medical devices, which is a growing problem worldwide, researchers are currently developing new “smart” materials and coatings. They consist in delivery of antimicrobial agents in an intelligent way, i.e., only when bacteria are present. This requires the use of new and sophisticated tools combining antimicrobial agents with lipids or polymers, synthetic and/or natural. In this review, three classes of innovative materials are described: hydrogels, nanomaterials, and thin films. Moreover, smart antibacterial materials can be classified into two groups depending on the origin of the stimulus used: those that respond to a nonbiological stimulus (light, temperature, electric and magnetic fields) and those that respond to a biological stimulus related to the presence of bacteria, such as changes in pH or bacterial enzyme secretion. The bacteria presence can induce a pH change that constitutes a first potential biological trigger allowing the system to become active. A second biological trigger signal consists in enzymes produced by bacteria themselves. A complete panel of recent studies will be given focusing on the design of such innovative smart materials that are sensitive to biological triggers.

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“…The SiO 2 NPs were prepared according to the sol-gel method [17,18]. About 760 mL of ammonia solution (37%), 2 ml of deionized water and 100 ml of absolute methanol were mixed in a round bottom flask and stirred vigorously for 5 min.…”

Section: Preparation Of Sio 2 Npsmentioning

confidence: 99%

The effect of SiO₂/Au core–shell nanoparticles on breast cancer cell’s radiotherapy

Darfarin

Salehi

Motlagh

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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pH-Controlled multiple-drug delivery by a novel antibacterial nanocomposite for combination therapy

Abstract: The modified cationic silica based stimuli responsive polymer–clay nanocomposite with pH responsive release manner could improve the targeting performance.

Cited by 49 publications

References 32 publications

Controlled drug delivery vehicles for cancer treatment and their performance

Controlled drug delivery vehicles for cancer treatment and their performance

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

The effect of SiO₂/Au core–shell nanoparticles on breast cancer cell’s radiotherapy

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pH-Controlled multiple-drug delivery by a novel antibacterial nanocomposite for combination therapy

Abstract: The modified cationic silica based stimuli responsive polymer–clay nanocomposite with pH responsive release manner could improve the targeting performance.

Cited by 49 publications

References 32 publications

Controlled drug delivery vehicles for cancer treatment and their performance

Controlled drug delivery vehicles for cancer treatment and their performance

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

The effect of SiO2/Au core–shell nanoparticles on breast cancer cell’s radiotherapy

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Product

Resources

About

The effect of SiO₂/Au core–shell nanoparticles on breast cancer cell’s radiotherapy