pH changes in root dentin over a 4-week period following root canal dressing with calcium hydroxide

Nerwich, Alan; Figdor, David; Messer, Harold H.

doi:10.1016/s0099-2399(06)80461-9

Cited by 248 publications

(283 citation statements)

References 15 publications

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“…For calcium hydroxide to be an effective root canal dressing, the hydroxyl ions must be able to diffuse through dentine to kill bacteria in dentinal tubules. Studies have shown that hydroxyl ions derived from calcium hydroxide do diffuse through root dentine, but the change produced in dentine pH is both time and distance dependent, 85,86 making the placement technique and the dressing period important factors to be considered in evaluating the antibacterial effects of calcium hydroxide. The vehicle in which calcium hydroxide is mixed to form the paste affects not only the physical and chemical properties of the compound but also its antimicrobial effects and its clinical application.…”

Section: Calcium Hydroxidementioning

confidence: 99%

The antimicrobial effects of root canal irrigation and medication

Karim

Kennedy

Hussey

2007

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Section: Calcium Hydroxidementioning

confidence: 99%

The antimicrobial effects of root canal irrigation and medication

Karim

Kennedy

Hussey

2007

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…It has been shown that this dressing needs to be in the root canal for at least 3-4 weeks in order to diffuse throughout the dentine and achieve effective pH values [16]. In this study, however, calcium hydroxide was left into the canal for 192 h only.…”

Section: Discussionmentioning

confidence: 88%

“…Nerwich et al [16] also reported in their study that it took nearly seven days for the pH to rise to 9.0, a level at which many bacteria do not grow.…”

Section: Discussionmentioning

confidence: 90%

“…Desirably, this would lead to a sufficiently high antimicrobial concentration able to eliminate the disease-causing bacteria in a predictable manner in both compartments [13,14]. To date, the most predictable antiseptic agent remains calcium hydroxide [15], which has been reported to be able to penetrate through the peripheral dentine [16]. Due to the complexity of root canal infections, however, it is unlikely that any single medicament results in an effective and predictable disinfection of the root canal complex, especially if antibiotic dressings are used [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Endodontic drug delivery for root surface disinfection: a laboratory feasibility evaluation

et al. 2015

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OBJECTIVES This study aims to assess the potential of a mixture of three antibiotics (TreVitaMix, TVM) as an intracanal dressing to disinfect the outer root surface by applying a new in vitro model. MATERIALS AND METHODS Fifty freshly extracted bovine roots were endodontically treated. Forty samples were then thoroughly scaled, mounted to petri dishes, gas sterilized, and randomly allocated to four groups (n = 10/group) according to their intracanal medication: sterile saline (NaCl; control, A); the TVM carrier material alone, i.e., propylene glycol (PG; B); TVM (C); and calcium hydroxide (D). In an additional group (E), the cementum was not removed and TVM was placed. Petri dishes were filled with Fastidious Anaerobe Agar, inoculated with Fusobacterium nucleatum suspension and then anaerobically incubated during 48-h intervals at 37°C up to 192 h. Inhibition zones around the roots were then measured after each incubation period (mm(2)). RESULTS Only teeth inoculated with the TVM dressing showed inhibition at all time points, whereas the other treatments showed no peri-radicular growing inhibition. Presence of cementum had no negative effect on disinfection (p = 0.9320). CONCLUSION TVM was able to penetrate through the dentine and inhibit the bacterial growth of F. nucleatum up to 192 h. CLINICAL RELEVANCE TVM might have the potential to sustainably disinfect the outer root surface in perio-endo lesions and serve as an adjunctive antimicrobial agent. Declaration of interests:The authors declare they have no conflicts of interest. AbstractObjectives To assess the potential of a mixture of three antibiotics (TreVitaMix, TVM) as an intracanal dressing to disinfect the outer root surface applying a new in vitro model. Materials and MethodsFifty freshly extracted bovine roots were endodontically treated. Forty samples were then thoroughly scaled, mounted to petri dishes, gas sterilized and randomly allocated to four groups (n=10/group) according their intracanal medication: Sterile saline NaCl (control, A), the TVM carrier material alone, i.e. propylene glycol (PG; B), TVM (C) and calcium hydroxide (D). In an additional group (E), the cementum was not removed and TVM was placed. Petri dishes were filled with Fastidiuos Anaerobe Agar, inoculated with F. nucleatum suspension and then anaerobically incubated during 48 h intervals at 37°C up to 192 h. Inhibition zones around the roots were then measured after each incubation period (mm 2 ).Results Only teeth inoculated with the TVM dressing showed inhibition at all time points, whereas the other treatments showed no peri-radicular growing inhibition. Presence of cementum had no negative effect on the disinfection (p = 0.9320).Conclusion TVM was able to penetrate through dentine and inhibit the bacterial growth of F. nucleatum up to 192 h.Clinical relevance TVM might have the potential to sustainably disinfect the outer root surface in perio-endo lesions and serve as an adjunctive antimicrobial agent.

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“…5 Ca(OH) 2 kimyasal formülüne sahip beyaz, kokusuz bir toz olan kalsiyum hidroksit (KH), sert doku oluşumunu indükleme, makul antimikrobiyal etkinlik ve doku çözücü özellikleriyle endodontide geniş kullanım alanına sahiptir. 6 Güçlü bir baz olan KH'nin (pH/12.5-12.8) kalsiyum ve hidroksil iyonlarına ayrışmasıyla bu iyonlar antibakteriyel aktiviteyi gerçekleştirir. 7 Kanal içi medikament olarak sıklıkla tercih edilen KH aynı zamanda bakteriler için fiziksel bariyer görevi görerek ve bakterilere besin geçişini engelleyerek antibakteriyel etki göstermektedir.…”

Section: Kök öRneklerinin Enfekte Edilmesiunclassified

Çeşitli Antiseptik Taşıyıcılarla Karıştırılan Kalsiyum Hidroksitin Enterococcus faecalis üzerindeki Antimikrobiyal Etkinliği

Akbulut

Güneşer

Eldeniz

2017

Selcuk Dental Journal

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Gereç ve Yöntemler:Altmış adet çekilmiş insan dişi örnekleri hazırlandı. Elli-beş tane kök segmenti E. faecalis ile 2 hafta boyunca enfekte edildi. Örnekler 5 deney grubuna ayrıldı (n=10) ve şu KH -antiseptik taşıyıcı karışımları uygulandı: Grup 1, KH + gliserin -distile su (7:1); Grup 2, KH + Octenisept; Grup 3, KH + %2'lik klorheksidin glukonat (CHX); Grup 4, KH + Savlex; Grup 5, KH + %5.25'lik sodyum hipoklorit (NaOCl). Antiseptik-KH karışımları 7 gün boyunca kök kanallarında bekletildi. Beş örnek sterilliği kontrol etmek için (negatif kontrol), beş örnek de pozitif kontrol olarak kullanıldı. Gates glidden frezler (# 3, 4, 5) yardımıyla kanal duvarlarından elde edilen dentin örnekleri fosfat-tamponlu salin (PBS) ve cam boncuk içeren şişelere aktarıldı ve 30 sn vortekslendi. Bakteri içeren PBS'ye seri dilüsyon yapıldı. Her bir dilüsyondan 25 μL halinde damlalar tripton soya agar plakları üzerine ekildi ve 37°C'de 48 saat inkübe edildi. Görünür koloni sayıları incelendi ve log 10 değerlerine dönüştürüldü. İstatistiksel analiz için Kruskal-Wallis ve Mann Whitney-U testleri kullanıldı. Bulgular:Negatif kontrol grubunda bakteri üremesi görülmezken pozitif kontrol grubunun bütün örneklerinde bakteri üremesi gözlemlenmiştir (log 10 3,47 CFU ml -1 ). Deney grupları arasında istatistiksel olarak anlamlı bir fark bulunmamıştır (p>0.05). KH + CHX ve KH + Savlex gruplarında E. faecalis biyofilmi tamamen elimine edilmiştir.Sonuç: Savlex, Octenisept ve NaOCl gibi çeşitli antiseptik ajanlar KH ile karıştırılarak kullanıldığında kök kanallarından E. faecalis'i elimine etmede etkili bulunmuştur. ANAHTAR KELİMELERAntimikrobiyal, E. faecalis, kanal-içi medikament, kök dentini ABSTRACT Antimicrobial activity of calcium hydroxide mixed with various antiseptic vehicles on Enterococcus faecalisBackground: The aim of this in vitro study was to test disinfection ability of different new antiseptic vehicle-calcium hydroxide (CH) combinations in root canals infected with Enterococcus faecalis using a dentin block model.

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pH changes in root dentin over a 4-week period following root canal dressing with calcium hydroxide

Cited by 248 publications

References 15 publications

The antimicrobial effects of root canal irrigation and medication

The antimicrobial effects of root canal irrigation and medication

Endodontic drug delivery for root surface disinfection: a laboratory feasibility evaluation

Çeşitli Antiseptik Taşıyıcılarla Karıştırılan Kalsiyum Hidroksitin Enterococcus faecalis üzerindeki Antimikrobiyal Etkinliği

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