pH and temperature responsive redox behavior of biologically important aniline derivatives

Subhan, Hanif; Lashin, Aref; Rana, Usman Ali; Al-Arifi, Nassir; Ahmad, Khurshid; Hussain, Hidayat; Qureshi, Rumana; Ali, Saqib; Zia, Muhammad Abid; Kraatz, Heinz‐Bernhard; Shah, Afzal

doi:10.1039/c5ra10822e

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…The position of the signal (labelled as 1a) observed at lower potential exhibited anodic shift with increase in pH due to the possibility of proton coupled electron transfer reaction. 45 While the signal labelled as 2a appearing in alkaline conditions showed no change in position with increasing pH. Thus, oxidation corresponding to signal 2a occurs by the loss of electron without accompaniment of proton.…”

Section: Cyclic Voltammetry (Cv)mentioning

confidence: 87%

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pH and Temperature Responsive Electrooxidation and Antioxidant Activity of Indole-3-Carbaldehyde

Subhan

Ahmad

Lashin

et al. 2016

J. Electrochem. Soc.

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Inspired by the broad range activities of indoles, we explored the antioxidant and electrochemical behavior of indole-3-carbaldehyde (I3C). The compound was first tested for cytotoxicity followed by the evaluation of its antioxidant activity using thiobarbituric acid-reactive species (TBARs). The selected indole was then investigated by several voltammetric techniques to gain insights about proposing its antioxidant action mechanism. Kinetics of the electrode reaction was probed by cyclic voltammetry experiments, which led to the determination of diffusibility constant and heterogeneous electron transfer rate constant. The feasibility of the redox event of 13C was judged from the thermodynamic parameters evaluated by observing the influence of temperature on the anodic response of the analyte. Square wave voltammetry (SWV) was employed for ensuring the reversible or irreversible nature of the oxidation reaction of I3C. Differential pulse voltammetry (DPV) was applied for the determination of number of electrons and protons involved in oxidation of the analyte. Moreover, DPV and SWV were used for the sensitive detection of I3C at bare and gold nanoparticles modified glassy carbon electrode. On the basis of voltammetric findings an oxidation mechanism supported by computational results was proposed with the objective of unravelling the antioxidant behavior of a representative of indoles.

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Section: Cyclic Voltammetry (Cv)mentioning

confidence: 87%

“…The shift peak 1a toward less positive potentials is consistent with the comparatively facile oxidation under alkaline conditions. 45 Fig. 4B shows peak potential of 1a as a function of pH.…”

Section: Cyclic Voltammetry (Cv)mentioning

confidence: 99%

pH and Temperature Responsive Electrooxidation and Antioxidant Activity of Indole-3-Carbaldehyde

Subhan

Ahmad

Lashin

et al. 2016

J. Electrochem. Soc.

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“…1 Electropolymers of aniline as well as its derivatives are prevalent as redox probes and electron transfer mediators. 2 Introduction of acidic groups on the polyaniline network improves its physical and chemical properties. 3 Para amino benzene sulfonic acid (ABSA), when electropolymerized on to glassy carbon electrode (GCE) has been reported to show better sensing performance than bare GCE for various chemical species.…”

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confidence: 99%

Poly(para amino benzene sulfonic acid) Modified Glassy Carbon Electrode for the Simultaneous as well as Individual Voltammetric Determination of Guanine, Adenine and Uric Acid

Jesny¹,

Kumar²

2018

J. Electrochem. Soc.

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The article details the development of a poly(para amino benzene sulfonic acid) modified glassy carbon electrode as a sensor for simultaneous determination of purine bases; guanine, adenine and uric acid. When 0.1 M NaOH was used as the supporting electrolyte the electro-oxidation of these analytes took place at well resolved electrode potentials which facilitated their simultaneous determination without any electrode fowling. The sensor response has been calibrated for both simultaneous and individual determination. Wide linear working concentration ranges and good detection limits were obtained for both. The selectivity of the sensor for simultaneous determination has been checked among these purine bases as well as in the presence of other possibly co-existing species. The sensor has been demonstrated to be efficient for determination of uric acid, guanine and adenine in acid denatured herring sperm DNA. The mechanistic and kinetic parameters such as charge transfer coefficient, number of electrons involved in the rate determining step, diffusion coefficient and heterogeneous rate constant for the electro-oxidation of these bases on the poly(para amino benzene sulfonic acid) modified glassy carbon electrode has also been determined.

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A selective and sensitive monitoring of the OH radical using flavonoid-modified electrodes

Jabeen

Ahmed

Domínguez‐Álvarez

et al. 2017

Electrochimica Acta

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pH and temperature responsive redox behavior of biologically important aniline derivatives

Abstract: The electrochemical oxidation of anilines resulted in azodye formation which was evidenced by the appearance of a new peak in the UV-visible spectra (A) and colour change of the solution (B).

Cited by 5 publications

References 40 publications

pH and Temperature Responsive Electrooxidation and Antioxidant Activity of Indole-3-Carbaldehyde

pH and Temperature Responsive Electrooxidation and Antioxidant Activity of Indole-3-Carbaldehyde

Poly(para amino benzene sulfonic acid) Modified Glassy Carbon Electrode for the Simultaneous as well as Individual Voltammetric Determination of Guanine, Adenine and Uric Acid

A selective and sensitive monitoring of the OH radical using flavonoid-modified electrodes

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