pH and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres

Zhu, Xinyun; Wang, Caiqi

doi:10.1016/j.jcis.2016.06.043

Cited by 30 publications

(24 citation statements)

References 55 publications

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“…Amino-functionalized MSNs were prepared after minor modification of previous works [19,32,33]. Briefly, the prepared MSN was dried at 140°C for 1 h. Then, 1 g of MSN was mixed into 7 ml of APTES.…”

Section: Methodsmentioning

confidence: 99%

Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

et al. 2018

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Targeted drug delivery to colon cancer cells can significantly enhance the therapeutic efficiency. Herein, we developed 5-fluorouracil (5-FU)-loaded amino-functionalized mesoporous silica nanoparticle (MSN-NH2)-based galactosylated chitosans (GCs), which are galactose receptor-mediated materials for colon-specific drug delivery systems. Both unmodified and functionalized nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, nitrogen sorption and dynamic light scattering. Drug loading capacity and drug release properties were determined by ultraviolet spectrophotometry. 5-FU@MSN-NH2/GC showed high loading capacity and possessed much higher cytotoxicity on human colon cancer cells (SW620 cells) than 5-FU@MSN-NH2 and free 5-FU. But, MSN-NH2/GC did not show significant cytotoxicity. Subsequently, 5-FU@MSN-NH2/GC anti-cancer activity on SW620 cells in vitro was confirmed by cell apoptosis. These results are consistent with the cellular uptake test in which MSN-NH2/GC could specifically recognize and bind to cancer cells by the galectin-receptor recognition. But, it is found that pre-addition of galactose in the medium, leading to competitive binding to the galectin receptor of SW620 cells, resulted in a decrease in the binding of MSN-NH2/GC to the galectin receptor. The results demonstrated the inorganic–organic nanocomposite could be used as a promising drug delivery carrier for the targeted delivery of drug into galectin-positive colon cancer cells to improve therapeutic index while reducing side effects.

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Section: Methodsmentioning

confidence: 99%

Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

et al. 2018

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“…As a typical example of multistimuli-responsive DDS, we note the pH and redox dual-responsive nanovalve with a long stalk on the surface of hollow mesoporous silica NPs (HMSs) designed for size-selective drug delivery. 240 The leakage of loaded rhodamine 6G (R6G) is insignicant in a neutral medium, which conrms the excellent sealing effect of the developed nanovalve (Fig. 31).…”

Section: Multi-stimuli-responsive Ddssmentioning

confidence: 98%

Recent advances in metallopolymer-based drug delivery systems

et al. 2019

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“…The mechanism behind the release is the strong electrostatic repulsion between β-CD and the oxidized hydrophilic ferrocenyl moiety which results in the dissociation of β-CD caps thus releasing the drug from the pores. The same carrier was also made pH-responsive by introducing an acetal linker to develop a synergistic effect [ 216 ].…”

Section: Applications Of Msns In Drug Deliverymentioning

confidence: 99%

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

et al. 2018

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Recent advancements in drug delivery technologies utilizing a variety of carriers have resulted in a path-breaking revolution in the approach towards diagnosis and therapy alike in the current times. Need for materials with high thermal, chemical and mechanical properties have led to the development of mesoporous silica nanoparticles (MSNs). These ordered porous materials have garnered immense attention as drug carriers owing to their distinctive features over the others. They can be synthesized using a relatively simple process, thus making it cost effective. Moreover, by controlling the parameters during the synthesis; the morphology, pore size and volume and particle size can be transformed accordingly. Over the last few years, a rapid increase in research on MSNs as drug carriers for the treatment of various diseases has been observed indicating its potential benefits in drug delivery. Their widespread application for the loading of small molecules as well as macromolecules such as proteins, siRNA and so forth, has made it a versatile carrier. In the recent times, researchers have sorted to several modifications in the framework of MSNs to explore its potential in drug resistant chemotherapy, antimicrobial therapy. In this review, we have discussed the synthesis of these multitalented nanoparticles and the factors influencing the size and morphology of this wonder carrier. The second part of this review emphasizes on the applications and the advances made in the MSNs to broaden the spectrum of its use especially in the field of biomedicine. We have also touched upon the lacunae in the thorough understanding of its interaction with a biological system which poses a major hurdle in the passage of this carrier to the clinical level. In the final part of this review, we have discussed some of the major patents filed in the field of MSNs for therapeutic purpose.

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pH and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres

Cited by 30 publications

References 55 publications

Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

Galactosylated chitosan-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery

Recent advances in metallopolymer-based drug delivery systems

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

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