pH and Redox Dual-Responsive MSN-S-S-CS as a Drug Delivery System in Cancer Therapy

Abstract

In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer–Emmett–Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.

Minimal vectorlike model in supersymmetric unification

“…Unlike in the 4-th generation leptons which directly mix with SM leptons, the VL electroweak fermions can be either produced via the decays of charginos and neutralinos, or they imitate the electroweak productions of charginos and neutralinos. The prospect of the later class at the high luminosity-LHC will be explored elsewhere [57].…”

Mesoporous Silica Nanoparticles: Properties and Strategies for Enhancing Clinical Effect

“…Prior to administration, complete characterization of MSNs is critical to approximating MSN behavior and correlating the theragnostic effect. Some of the common methods for verifying MSN properties by analyzing synthesized particles are dynamic light scattering (DLS) [ 23 ] and transmission electron microscopy (TEM); and by analyzing the specific surface area calculations through the Brunauer–Emmett–Teller (BET) methods [ 24 ]. Understanding how the tunable traits of MSNs influence potential theragnostic action is critical to optimizing clinical efficacy.…”

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

“…By using a disulfide bond to link the MSNs and chitosan, a redox responsive system was created. With a high concentration of GSH, the disulfide bond was broken, which lead to chitosan gate opening and release of the drug [ 202 , 203 , 204 ]. Besides simultaneous use of pH and redox stimulus, there have been reports on pH and ROS stimulus being used.…”