2015
DOI: 10.1002/adfm.201404484
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pH‐ and NIR Light‐Responsive Micelles with Hyperthermia‐Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer

Abstract: The acquisition of multidrug resistance (MDR) is a major hurdle for the successful chemotherapy of tumors. Herein, a novel hybrid micelle with pH and near‐infrared (NIR) light dual‐responsive property is reported for reversing doxorubicin (DOX) resistance in breast cancer. The hybrid micelles are designed to integrate the pH‐ and NIR light‐responsive property of an amphiphilic diblock polymer and the high DOX loading capacity of a polymeric prodrug into one single nanocomposite. At physiological condition (i.e… Show more

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Cited by 236 publications
(164 citation statements)
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“…[ 2 ] Mono or combinational chemotherapy is currently the main approach for treating metastatic breast cancer, [ 3 ] but it suffered from the low bioavailability and the serious side effect of small molecular anti-cancer drugs. [ 4 ] Nanosized drug delivery systems (NDDS) could signifi cantly improve the dispersity of water insoluble anticancer drugs, and effi ciently deliver them to the solid tumor through the enhanced penetration and retention (EPR) effect since the tumoral neovasculature is of leakage structure. [ 5 ] Despite promising, the therapeutic efficiency of current NDDS against metastatic tumors was severely impaired due to two intrinsic limitations of nanodrugs, one is their limited blood circulation mainly due to recognition by the reticule endothelial system (RES), [ 6 ] which could cause sublethal tumor distribution of the anticancer drugs.…”
Section: Introductionmentioning
confidence: 99%
“…[ 2 ] Mono or combinational chemotherapy is currently the main approach for treating metastatic breast cancer, [ 3 ] but it suffered from the low bioavailability and the serious side effect of small molecular anti-cancer drugs. [ 4 ] Nanosized drug delivery systems (NDDS) could signifi cantly improve the dispersity of water insoluble anticancer drugs, and effi ciently deliver them to the solid tumor through the enhanced penetration and retention (EPR) effect since the tumoral neovasculature is of leakage structure. [ 5 ] Despite promising, the therapeutic efficiency of current NDDS against metastatic tumors was severely impaired due to two intrinsic limitations of nanodrugs, one is their limited blood circulation mainly due to recognition by the reticule endothelial system (RES), [ 6 ] which could cause sublethal tumor distribution of the anticancer drugs.…”
Section: Introductionmentioning
confidence: 99%
“…In the last few years, amphiphilic nanocarrier which are responsive to specific external stimuli such as light, temperature 178,179 , near infrared reflection (NIR) 180,181 and ultrasound also have been designed and developed. Most of them have achieved a good effect on killing tumor cells and overcoming the MDR (Figure 8).…”
Section: Use Peg-based Amphiphilic Nanostructures To Overcome Chemmentioning
confidence: 99%
“…Our laboratory reported polymer-based acid and NIR light dual-responsive micelle NPs for the treatment of DOXresistant breast cancer [5] . The micelles were composed of a pHresponsive diblock polymer and a polymeric prodrug of DOX ( Figure 3A and 3B).…”
Section: Overcoming Extracellular Barriers Using Nanomedicinementioning
confidence: 99%
“…Solid tumors are highly heterogeneous [3,4] , which are surrounded by a dense extracellular matrix (ECM) and lack lymphatic drainage. These factors synergistically induce a reduced transcapillary pressure gradient and an elevated interstitial fluid pressure (IFP), which restricts drug distribution within the tumor [5,6] . Moreover, accumulating evidence indicates that the drug-resistant tumor cells produce more acidic vesicles than normal cells.…”
Section: Introductionmentioning
confidence: 99%