pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats

Wang, Lu; Li, Yuzhou; Ren, Maozhi; Wang, Xu; Li, Lingjie; Liu, Fengyi; Lan, Yiqing; Yang, Sheng; Song, Jinlin

doi:10.1016/j.bioactmat.2022.02.008

Cited by 34 publications

(34 citation statements)

References 59 publications

(76 reference statements)

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“…A growing number of drug delivery systems have been developed using pH-responsive polymers, making PGS- co -PEG copolymers suitable for these applications. 49 …”

Section: Resultsmentioning

confidence: 99%

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

et al. 2022

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“…A growing number of drug delivery systems have been developed using pH-responsive polymers, making PGS- co -PEG copolymers suitable for these applications. 49 …”

Section: Resultsmentioning

confidence: 99%

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

et al. 2022

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“…It is well recognized that excess and prolonged host inflammatory response could reprogram the cellular energy metabolism in periodontal tissue from oxidative phosphorylation to anaerobic glycolysis, leading to the occurrence of extracellular acidification. 47 , 48 Therefore, an acidic pH could serve as an external stimulus to control the release of anti-inflammatory agents for the regulation of cell behaviors via a self-modulatory mechanism under inflammatory conditions. 49 , 50 Figure 2F shows the drug release profiles of aspirin-laden nanocomposites at two different pH values: 5.5 and 7.4.…”

Section: Resultsmentioning

confidence: 99%

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Chen¹,

Zhang²,

He³

et al. 2022

IJN

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The functional reconstruction of periodontal tissue defects remains a clinical challenge due to excessive and prolonged host response to various endogenous and exogenous pro-inflammatory stimuli. Thus, a biomimetic nanoplatform with the capability of modulating inflammatory response in a microenvironment-responsive manner is attractive for regenerative therapy of periodontal tissue. Methods: Herein, a facile and green design of engineered bone graft materials was developed by integrating a biomimetic apatite nanocomposite with a smart-release coating, which could realize inflammatory modulation by "on-demand" delivery of the antiinflammatory agent through a pH-sensing mechanism. Results: In vitro and in vivo experiments demonstrated that this biocompatible nanoplatform could facilitate the clearance of reactive oxygen species in human periodontal ligament stem cells under inflammatory conditions via inhibiting the production of endogenous proinflammatory mediators, in turn contributing to the enhanced healing efficacy of periodontal tissue. Moreover, this system exhibited effective antimicrobial activity against common pathogenic bacteria in the oral cavity, which is beneficial for the elimination of exogenous pro-inflammatory factors from bacterial infection during healing of periodontal tissue. Conclusion:The proposed strategy provides a versatile apatite nanocomposite as a promising "inflammation scavenger" and propels the development of intelligent bone graft materials for periodontal and orthopedic applications.

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“…General RNA of every group of cells was obtained by Trizol reagent (Invitrogen) 55 . After the cells were lysed by Trizol reagent, the supernatant containing RNA was separated by chloroform, and then isopropyl alcohol was added to precipitate RNA, which was washed with 70% ethanol, and finally RNA was dissolved in non-enzymatic water.…”

Section: Methodsmentioning

confidence: 99%

Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells

Luo

et al. 2022

Sci Rep

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Mage-D1 (MAGE family member D1) is involved in a variety of cell biological effects. Recent studies have shown that Mage-D1 is closely related to tooth development, but its specific regulatory mechanism is unclear. The purpose of this study was to investigate the expression pattern of Mage-D1 in rat dental germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. Results showed that the expression of Mage-D1 during rat dental germ development was temporally and spatially specific. Mage-D1 promotes the proliferation ability of EMSCs but inhibits their migration ability. Under induction by mineralized culture medium, Mage-D1 promotes osteogenesis and tooth-forming ability. Furthermore, the expression pattern of Mage-D1 at E19.5 d rat dental germ is similar to p75 neurotrophin receptor (p75NTR), distal-less homeobox 1 (Dlx1) and msh homeobox 1 (Msx1). In addition, Mage-D1 is binding to p75NTR, Dlx1, and Msx1 in vitro. These findings indicate that Mage-D1 is play an important regulatory role in normal mineralization of teeth. p75NTR, Dlx1, and Msx1 seem to be closely related to the underlying mechanism of Mage-D1 action.

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pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats

Cited by 34 publications

References 59 publications

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

Elastomeric, bioadhesive and pH-responsive amphiphilic copolymers based on direct crosslinking of poly(glycerol sebacate)-co-polyethylene glycol

A Biomimetic Smart Nanoplatform as “Inflammation Scavenger” for Regenerative Therapy of Periodontal Tissue

Dynamic expression of Mage-D1 in rat dental germs and potential role in mineralization of ectomesenchymal stem cells

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