pH and glutathion-responsive hydrogel for localized delivery of paclitaxel

Pérez, Elena; Fernandez, Angela; Olmo, Rosa; Teijón, José M.; Blanco, Marcos

doi:10.1016/j.colsurfb.2014.01.004

Cited by 33 publications

(36 citation statements)

References 39 publications

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“…Despite the success of novel strategies such as soluble derivatives or prodrugs, [1][2][3] the strategy using a delivery system is still a predominant approach, particularly considering its potential to achieve targeted delivery or codelivery of different components. [4][5][6] In recent years, various types of materials have been investigated as delivery systems for hydrophobic drugs, including, but not limited to, liposomes, 7 polymeric nanoparticles, [8][9][10] hydrogels, 11,12 and carbon nanotubes. [13][14][15] Several wellstudied materials have been developed into clinically available formulations, such as Abraxane ® and Doxil ® .…”

Section: Introductionmentioning

confidence: 99%

Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

Chen¹,

Tang²,

Zhang³

et al. 2015

IJN

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Background Finding a suitable delivery system to improve the water solubility of hydrophobic drugs is a critical challenge in the development of effective formulations. In this study, we used A 6 K, a self-assembling surfactant-like peptide, as a carrier to encapsulate and deliver hydrophobic pyrene. Methods Pyrene was mixed with A 6 K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well as the pyrene release profile. Results The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A 6 K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers. The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A 6 K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells. Conclusion A 6 K could be further exploited as a promising delivery system for hydrophobic drugs.

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Section: Introductionmentioning

confidence: 99%

Self-assembling surfactant-like peptide A6K as potential delivery system for hydrophobic drugs

Chen¹,

Tang²,

Zhang³

et al. 2015

IJN

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“…Perez et al [115] formulated a pH and glutathion-responsive, PTX-loaded poly- N -isopropylacrylamide (NIPA), tert-butyl 2-acrylamidoethyl carbamate (2AAECM) and N -hydroxyethyl acrylamide (HEAA)-based nanohydrogel by a microemulsion polymerization method comprising N , N '-cystaminebisacrylamide (CBA) as crosslinker. The developed formulations were assessed for cytotoxicity and cellular uptake studies using MTT assay and Coumarin-6, respectively, against cancer cell lines (MCF-7, T47D, and HeLa).…”

Section: Localized Drug Delivery Systemsmentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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“…In vitro characterisation of these stimuli-responsive NG revealed a nanometre size in the swollen state and good cytocompatibility in studies conducted with different tumour cell lines (MCF7, HeLa and T47D). Moreover, nanosystems containing disulphide linkages in their network composition, such as the CBA cross-linking agent, demonstrated a bioreducible response when they were in contact with reducing intracellular medium conditions [19]. In contrast, nanohydrogels containing NMBA did not show that redox response, as this crosslinking-agent provided more stable network particles [20].…”

Section: Introductionmentioning

confidence: 97%

“…In our previous works, new stimuli-responsive nanohydrogels (NG) based on poly-N-isopropylacrylamide (NIPA), N-hydroxyethyl acrylamide (HEAA) and tert-butyl 2-acrylamidoethyl carbamate (2AAECM) were synthesised by a microemulsion polymerisation method using two different crosslinking agents: N, N-cystaminebisacrylamide (CBA) [19] and Nmethylenebisacrylamide (NMBA) [20]. In vitro characterisation of these stimuli-responsive NG revealed a nanometre size in the swollen state and good cytocompatibility in studies conducted with different tumour cell lines (MCF7, HeLa and T47D).…”

Section: Introductionmentioning

confidence: 99%