PH-0551 Modulated electro-hyperthermia improves three year survival in cervical cancer patients

Minnaar, Carrie Anne; Kotzen, Jeffrey; Baeyens, Ans; Vangu, M.D.T.H.W.

doi:10.1016/s0167-8140(21)07361-8

Cited by 2 publications

(2 citation statements)

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“…The heterogenic selection principle proposes a solution to the challenge of tissue selection in hyperthermia [ 91 ] by applying non-isothermal heating [ 92 ]. We use the principles of modulated electro-hyperthermia (mEHT), which has already demonstrated its clinical benefits, improving outcomes for patients when combined with chemotherapy and radiotherapy [ 93 , 94 , 95 ]. The mEHT synergically utilizes mild heating, which improves blood flow and perfusion [ 96 ] and the modulated electric field [ 97 ].…”

Section: Electromagnetic Methods Of Hyperthermia In Oncologymentioning

confidence: 99%

Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field

Minnaar

Szász

2022

Cells

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The role of Heat Shock Proteins (HSPs) is a “double-edged sword” with regards to tumors. The location and interactions of HSPs determine their pro- or antitumor activity. The present review includes an overview of the relevant functions of HSPs, which could improve their antitumor activity. Promoting the antitumor processes could assist in the local and systemic management of cancer. We explore the possibility of achieving this by manipulating the electromagnetic interactions within the tumor microenvironment. An appropriate electric field may select and affect the cancer cells using the electric heterogeneity of the tumor tissue. This review describes the method proposed to effect such changes: amplitude-modulated radiofrequency (amRF) applied with a 13.56 MHz carrier frequency. We summarize the preclinical investigations of the amRF on the HSPs in malignant cells. The preclinical studies show the promotion of the expression of HSP70 on the plasma membrane, participating in the immunogenic cell death (ICD) pathway. The sequence of guided molecular changes triggers innate and adaptive immune reactions. The amRF promotes the secretion of HSP70 also in the extracellular matrix. The extracellular HSP70 accompanied by free HMGB1 and membrane-expressed calreticulin (CRT) form damage-associated molecular patterns encouraging the dendritic cells’ maturing for antigen presentation. The process promotes killer T-cells. Clinical results demonstrate the potential of this immune process to trigger a systemic effect. We conclude that the properly applied amRF promotes antitumor HSP activity, and in situ, it could support the tumor-specific immune effects produced locally but acting systemically for disseminated cells and metastatic lesions.

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Section: Electromagnetic Methods Of Hyperthermia In Oncologymentioning

confidence: 99%

Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field

Minnaar

Szász

2022

Cells

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“…The cervix cancers were studied in a Phase III double-arm randomized prospective controlled trial involving two–two groups in both arms, patients ±HIV [ 67 , 68 ]. Metabolic response (MR) was measured by PET [ 69 ].…”

Section: Clinical Validationmentioning

confidence: 99%

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

Lee,

Lorant,

Grand

et al. 2023

Cancers

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The mEHT method uses tissues’ thermal and bioelectromagnetic heterogeneity for the selective mechanisms. The success of the therapy for advanced, relapsed, and metastatic aggressive tumors can only be demonstrated by measuring survival time and quality of life (QoL). The complication is that mEHT-treated patients cannot be curatively treated any longer with “gold standards”, where the permanent progression of the disease, the refractory, relapsing situation, the organ failure, the worsening of blood counts, etc., block them. Collecting a cohort of these patients is frequently impossible. Only an intent-to-treat (ITT) patient group was available. Due to the above limitations, many studies have single-arm data collection. The Phase III trial of advanced cervix tumors subgrouping of HIV-negative and -positive patients showed the stable efficacy of mEHT in all patients’ subgroups. The single-arm represents lower-level evidence, which can be improved by comparing the survival data of various studies from different institutes. The Kaplan–Meier probability comparison had no significant differences, so pooled data were compared to other methods. Following this approach, we demonstrate the feasibility and superiority of mEHT in the cases of glioblastoma multiform, pancreas carcinomas, lung tumors, and colorectal tumors.

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PH-0551 Modulated electro-hyperthermia improves three year survival in cervical cancer patients

Cited by 2 publications

References 0 publications

Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field

Forcing the Antitumor Effects of HSPs Using a Modulated Electric Field

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

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