PH-0361: Reactivation of HCMV during RT of the brain results in critical illness and early mortality

Frey, Bruce B.; Goerig, Nicole L.; Ina, B.; Anna-Jasmina, D.; Klaus, Kristel; Klaus, U.; Manuel, S T; Arnd, D.; Tobías, Ester; Ilker, E.; Florian, Peter; Schlyer, Sabine; Udo, G.; Rainer, Silvia

doi:10.1016/s0167-8140(21)00385-6

Cited by 1 publication

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“…Blood samples from 1561 patients with glioblastoma were analyzed using PCR methods (883 samples) [24,26,27,[29][30][31]50,53,76,79,80,82,[84][85][86], flow cytometry (288 samples) [32,36,45,49,53,64], and serology tests (1249 samples) [22,24,27,30,34,35,37,38,48,51,53,58,62,65,70,72,76,82,86,88].…”

Section: Analyses Of Blood Samples To Detect Hcmv Dna Hcmv-specific Antibodies or Hcmv-reactive T-cells To Hcmvmentioning

confidence: 99%

Presence of the Human Cytomegalovirus in Glioblastomas—A Systematic Review

Peredo-Harvey

Rahbar

Söderberg‐Nauclér

2021

Cancers

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Glioblastoma is a malignant brain tumor with a dismal prognosis. The standard treatment has not changed in the past 15 years as clinical trials of new treatment protocols have failed. A high prevalence of the human cytomegalovirus (HCMV) in glioblastomas was first reported in 2002. The virus was found only in the tumor and not in the surrounding healthy brain tissue. Many groups have confirmed the presence of the HCMV in glioblastomas, but others could not. To resolve this discrepancy, we systematically reviewed 645 articles identified in different databases. Of these, 81 studies included results from 247 analyses of 9444 clinical samples (7024 tumor samples and 2420 blood samples) by different techniques, and 81 articles included 191 studies that identified the HCMV in 2529 tumor samples (36% of all tumor samples). HCMV proteins were often detected, whereas HCMV nucleic acids were not reliably detected by PCR methods. Optimized immunohistochemical techniques identified the virus in 1391 (84,2%) of 1653 samples. These data suggest that the HCMV is highly prevalent in glioblastomas and that optimized immunohistochemistry techniques are required to detect it.

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