PGI22 Evaluating Health-Related Quality of Life (HRQoL) in Patients with and without Crohn?s Perianal Fistulas (CPF) Using the Euroqol Five-Dimension (EQ-5D-5L) Questionnaire in a Real-World US Setting

Jiang, Jeanne; Nazarey, Pradeep; Kuharic, Maja; Athavale, Amod; Fan, Tao; Silber, Abigail; Abilash, Vijay; Hadker, Nandini; Sharpe, Emily E.; Cazzetta, Susan

doi:10.1016/j.jval.2021.04.512

Value in Health

2021

DOI: 10.1016/j.jval.2021.04.512

|View full text |Cite

PGI22 Evaluating Health-Related Quality of Life (HRQoL) in Patients with and without Crohn?s Perianal Fistulas (CPF) Using the Euroqol Five-Dimension (EQ-5D-5L) Questionnaire in a Real-World US Setting

Jeanne Jiang

Pradeep Nazarey

Maja Kuharic

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Scoring Indices for Perianal Fistulising Crohn’s Disease: A Systematic Review

Vuyyuru,

Solitano,

Singh

et al. 2023

Journal of Crohn's and Colitis

View full text Add to dashboard Cite

Background & Aims In this systematic review we summarize existing scoring indices for assessing disease activity and quality of life in perianal fistulizing Crohn’s disease (PFCD) and highlight gaps in the literature. Methods MEDLINE, EMBASE, and CENTRAL were searched from 24 August 2022 to identify studies evaluating clinical, radiological, or patient-reported outcome measures (PROMS) in PFCD. The primary objective was to identify all available scoring indices and describe the operating properties of these indices. Results Fifty-three studies reported on the use of one clinical index (Perianal Disease Activity Index: PDAI), three PROMs and ten radiological indices. Twenty-five studies evaluated the operating properties of these indices. The PDAI demonstrated content validity, construct validity and responsiveness but criterion validity or reliability were not assessed. The Van Assche index (VAI), modified VAI and the Magnetic Resonance Index for Assessing Fistulas in Patients with CD (MAGNIFI-CD) were the most studied radiological indices. These indices demonstrated responsiveness and reliability. The VAI and MAGNIFI-CD demonstrated construct validity. Criterion and content validity and feasibility have not been assessed. Among the three PROMs, the Crohn’s Anal Fistula Quality of Life index demonstrated content and construct validity, inter-observer reliability and responsiveness. Criterion validity, intra-observer reliability and feasibility have not been assessed for this index. Conclusions There are no fully valid, reliable, and responsive clinical disease or radiological indices for PFCD. Although the radiological indices demonstrated responsiveness and reliability, well-defined cut-offs for response and remission are lacking. Future research should focus on establishing standardized definitions and thresholds for outcomes.

show abstract

Scoring Indices for Perianal Fistulising Crohn’s Disease: A Systematic Review

Vuyyuru,

Solitano,

Singh

et al. 2023

Journal of Crohn's and Colitis

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

PGI22 Evaluating Health-Related Quality of Life (HRQoL) in Patients with and without Crohn?s Perianal Fistulas (CPF) Using the Euroqol Five-Dimension (EQ-5D-5L) Questionnaire in a Real-World US Setting

Cited by 1 publication

References 0 publications

Scoring Indices for Perianal Fistulising Crohn’s Disease: A Systematic Review

Scoring Indices for Perianal Fistulising Crohn’s Disease: A Systematic Review

Contact Info

Product

Resources

About