PGF2α and its Metabolites in Uterine and Jugular Venous Plasma and Endometrium of Ewes during Pregnancy

Section: Introductionmentioning

confidence: 99%

Oestrogen receptors and protein synthesis in caruncular and intercaruncular endometrium of sheep before implantation

Findlay¹,

Clarke²,

Swaney³

et al. 1982

“…We have observed that the release of oxytocin-neurophysin and oxytocin which follows the pulsatile release of PGF-2a during luteolysis originates from the ovary . Consequently, the oxytocin-secreting cells in the CL are likely to be exposed to a greater concentration of PGF than the peripheral levels because of the countercurrent transfer of PGF-2a and possibly also PGF metabolites (Lewis et ., 1977) from the uterine vein in the ovarian artery (McCracken et al, 1972;Pexton et al, 1975). There is also evidence that PGF-2a can reach the CL from the uterus by the lymphatic system (Heap et ai, 1985;Abdel Rahim et ai, 1984a, b).…”

Section: Resultsmentioning

confidence: 99%

Effect of systemic intravenous infusion of PGF-2 and 13,14-dihydro-15-keto-PGF-2 on the release of oxytocin-associated neurophysin from the ovary in the ewe

Watkins¹,

Moore²

1987

Summary. Systemic intravenous infusion of physiological concentrations of PGF-2\g=a\ and its major metabolite, 13,14-dihydro-15-keto-PGF-2\g=a\(PGFM) into non-pregnant ewes possessing a corpus luteum induced the release of oxytocin\p=m-\neurophysin.These results suggest that, during luteolysis, endogenous release of uterine PGF-2\g=a\would be able to stimulate the release of ovarian oxytocin and oxytocin\p=m-\neurophysinfrom the ovary.

“…In a recent review of this question, Wathes and Lamming (1995) Goff, 1985), ewes (Fairclough et al, 1984) and mares (Goff et al, 1987) and the pulsatile peaks of PGFM in peripheral plasma observed during luteolysis in these species are also abolished in pregnancy (Kindahl et al, 1976;Peterson et al, 1976;Webb et al, 1981 (Wilson et al, 1972), or similar to (Pexton et al, 1975;Lewis et al, 1977) (Payne and Lamming, 1994 …”

Section: Discussionmentioning

confidence: 99%

Control of luteolysis in the one-humped camel (Camelus dromedarius)

Skidmore¹,

Starbuck²,

Ge³

et al. 1998

Blood plasma concentrations of 13,14-dihydro-15-keto PGF2\g=a\(PGFM) were Furthermore, reduction in the amount of PGF2\g=a\ released is associated with luteal maintenance and the embryonic signal for maternal recognition of pregnancy must be transmitted before day 10 after ovulation if luteostasis is to be achieved. However, the results also indicate that, in contrast to ruminants, the release of endometrial PGF2\g=a\ in the non-pregnant camel may not be controlled by the release of oxytocin.