2021
DOI: 10.1016/j.mito.2021.03.013
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PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia

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Cited by 25 publications
(39 citation statements)
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“…POLRMT is essential for mtDNA transcription and OXPHOS [ 12 , 23 , 24 ]. Recent studies have proposed POLRMT as a novel metabolic oncogene for human cancers [ 15 , 26 , 27 ]. Chaudhary et al reported that POLRMT is overexpressed in acute myeloid leukemia (AML), which is associated with increased mtDNA copy number and lower patients’ survival [ 26 ].…”
Section: Discussionmentioning
confidence: 99%
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“…POLRMT is essential for mtDNA transcription and OXPHOS [ 12 , 23 , 24 ]. Recent studies have proposed POLRMT as a novel metabolic oncogene for human cancers [ 15 , 26 , 27 ]. Chaudhary et al reported that POLRMT is overexpressed in acute myeloid leukemia (AML), which is associated with increased mtDNA copy number and lower patients’ survival [ 26 ].…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have proposed POLRMT as a novel metabolic oncogene for human cancers [ 15 , 26 , 27 ]. Chaudhary et al reported that POLRMT is overexpressed in acute myeloid leukemia (AML), which is associated with increased mtDNA copy number and lower patients’ survival [ 26 ]. Bralha et al reported that in AML cells shRNA-induced POLRMT silencing decreased mitochondrial gene expression, OXPHOS, and expressions of subunits of respiratory chain complexes, but increased cell death [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
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“…POLRMT is essential for mtDNA transcription and OXPHOS [ 26 28 ], represents as a novel therapeutic target for human cancer [ 15 , 18 , 29 ]. POLRMT overexpression in AML is associated increased mtDNA copy number and lower overall survival [ 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…POLRMT is essential for mtDNA transcription and OXPHOS [ 26 28 ], represents as a novel therapeutic target for human cancer [ 15 , 18 , 29 ]. POLRMT overexpression in AML is associated increased mtDNA copy number and lower overall survival [ 29 ]. In AML cells, POLRMT knockdown by shRNA reduced mitochondrial gene expression and inhibited OXPHOS and expression of respiratory chain complex subunits, causing significant cell death [ 15 ].…”
Section: Discussionmentioning
confidence: 99%