PGC-1α may associated with the anti-obesity effect of taurine on rats induced by arcuate nucleus lesion

Cao, Peng-juan; Jin, Yongjun; Li, Minge; Zhou, Rong; Yang, Meizi

doi:10.1179/1476830514y.0000000153

Cited by 35 publications

(26 citation statements)

References 38 publications

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“…In addition, taurine increased mRNA expression of their target genes, including lipoprotein lipase, acyl‐CoA oxidase, acyl‐CoA synthetase, and medium‐chain acyl‐CoA dehydrogenase. Similarly, taurine supplementation administered to MSG‐induced obese rats reduced body fat and improved lipid metabolism . These effects of taurine were associated with elevated body temperatures, increased brown adipose tissues, and increased PGC‐1α levels.…”

Section: Antiobesity Mechanisms Of Taurinementioning

confidence: 94%

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Role of taurine in the pathogenesis of obesity

Murakami

2015

Molecular Nutrition Food Res

126

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Taurine is a sulfur-containing amino acid that is present in mammalian tissues in millimolar concentrations. Taurine is involved in a diverse array of biological and physiological functions, including bile salt conjugation, osmoregulation, membrane stabilization, calcium modulation, anti-oxidation, and immunomodulation. The prevalence of obesity and being overweight continues to rise worldwide at an alarming rate. Obesity is associated with a higher risk of metabolic and cardiovascular diseases, cancer, and other clinical conditions. Ingestion of taurine has been shown to alleviate metabolic diseases such as hyperlipidemia, diabetes, hypertension, and obesity in animal models. A global epidemiological survey showed that 24-h urinary taurine excretion, as a marker of dietary taurine intake, was inversely associated with BMI, blood pressure, and plasma cholesterol in humans. In addition, taurine chloramine, an endogenous product derived from activated neutrophils, has been reported to suppress obesity-induced oxidative stress and inflammation in adipocytes. Synthetic activity and concentration of taurine in adipose tissues and plasma have been shown to decrease in humans and animals during the development of obesity, suggesting a relationship between taurine deficiency and obesity. In this review, I summarize the effects of taurine on the progression of obesity in animal models and humans. Furthermore, I discuss possible mechanisms underlying the antiobesity effects of taurine.

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Section: Antiobesity Mechanisms Of Taurinementioning

confidence: 94%

“…Cao et al. examined the effect of taurine in the same MSG‐induced obesity model of rats. A 5‐week taurine‐treatment reduced the BMI, and improved the plasma lipid levels.…”

Section: Antiobesity Effects Of Taurinementioning

confidence: 99%

Role of taurine in the pathogenesis of obesity

Murakami

2015

Molecular Nutrition Food Res

126

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“…Taurine, a mammalian amino acid, was shown to protect neurons from glutamate cytotoxicity, maintain MMP, and reduce ROS in SH-SY5Y cells [222]. Taurine also protected mitochondria by activating Akt-CREB-peroxisome proliferator-activated receptor gamma co-activator 1-α (PGC1α) pathway [223,224,225]. In prenatally-stressed (PS) rats that had defects in learning and memory, taurine reduced mitochondrial ROS, restored MMP, COX, ATP, and SOD2, and increased Akt-CREB signaling pathway and PGC1α expression in the hippocampi [223].…”

Section: Natural Compounds That Can Activate Nrf2 And/or Neurotropmentioning

confidence: 99%

Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?

Murphy

Park

2017

IJMS

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Alzheimer’s disease (AD) is a multifaceted disease that is hard to treat by single-modal treatment. AD starts with amyloid peptides, mitochondrial dysfunction, and oxidative stress and later is accompanied with chronic endoplasmic reticulum (ER) stress and autophagy dysfunction, resulting in more complicated pathogenesis. Currently, few treatments can modify the complicated pathogenic progress of AD. Compared to the treatment with exogenous antioxidants, the activation of global antioxidant defense system via Nrf2 looks more promising in attenuating oxidative stress in AD brains. Accompanying the activation of the Nrf2-mediated antioxidant defense system that reduce the AD-causative factor, oxidative stress, it is also necessary to activate the neurotrophic signaling pathway that replaces damaged organelles and molecules with new ones. Thus, the dual actions to activate both the Nrf2 antioxidant system and neurotrophic signaling pathway are expected to provide a better strategy to modify AD pathogenesis. Here, we review the current understanding of AD pathogenesis and neuronal defense systems and discuss a possible way to co-activate the Nrf2 antioxidant system and neurotrophic signaling pathway with the hope of helping to find a better strategy to slow AD.

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“…Lin et al [13] indicated that taurine treatment attenuates the infiltration of adipose tissue by macrophages and modulates the phenotype of macrophages, which suggest that taurine is a valuable food constituent with a potential to attenuate chronic inflammation in adipose tissue and improve obesityrelated insulin resistance. Cao et al [14] suggested that taurine prevents obesity in monosodium glutamate (MSG)-treated rats and may be closely associated with energy metabolism.…”

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confidence: 99%