PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle

Abstract

Wojtaszewski JF, Pilegaard H. PGC-1␣ is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle.

PGC-1α, glucose metabolism and type 2 diabetes mellitus

“…Phosphorylation of AS160 can activate Rab proteins in GLUT4 vesicles and promote its translocation to the plasma membrane (Satoh 2014). Two recent reports have reported that PGC-1α is essential for AICAR-induced expression of GLUT4 (Leick et al 2010, Suwa et al 2015. These results are consistent with the previous report that modest PGC-1α overexpression in obese Zucker rat muscles can increase insulin-induced AS160 phosphorylation (Benton et al 2010).…”

Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes

“…In particular, Armoni et al reported that various fatty acids, including arachidonic acid, stearic acid, oleic acid, and linoleic acid, repressed GLUT4 promoter activity in cardiac muscle cells (Armoni et al, 2005a,b). AMPK has been reported to directly increase GLUT4 expression through the phosphorylation of HDAC5 (McGee et al, 2008) and the upregulation of PGC1a (Leick et al, 2010). However, AMPK activators may indirectly upregulate GLUT4 expression through FAO stimulation, given that the acetyl-CoA carboxylase inhibitor TOFA, which reduces malonyl-CoA as an inhibitor of CPT-1, and the PPARa agonist Bez, which acts downstream of AMPK, also upregulated GLUT4 gene expression.…”

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

“…24,25 However, little is known about the profiles of PPARGC1A and other genes involved in mitochondrial biogenesis in macrophages. We next investigated whether AICAR treatment of BMDMs leads to the induction of PPARGC1A and genes regulating mitochondrial biogenesis.…”