PGC-1α in mediating mitochondrial biogenesis and intestinal epithelial differentiation promoted by purple potato extract

Sun, Qi; Iniguez, Alejandro Bravo; Tian, Qiyu; Du, Min; Zhu, Mei‐Jun

doi:10.1016/j.jff.2022.105291

Cited by 10 publications

(7 citation statements)

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“…[ 45 ] Similarly, activation of the AMPK signaling has linked to decreased claudin2 in Caco‐2 cells. [ 22 ] Consistent with decreased claudin2, our data showed activation of both ERK and AMPK signaling in the CBD group. Colon tissues from IBD patients show enhanced epithelial MLCK expression and subsequent MLC2 phosphorylation, which localize to the apical actomyosin ring at the site of the intercellular junction and potentially contribute to gut barrier dysfunction and IBD pathogenesis.…”

Section: Discussionsupporting

confidence: 73%

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS‐Induced Colitis Mice

Sun,

Bravo Iniguez,

Tian

et al. 2024

Molecular Nutrition Food Res

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ScopeInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut, accompanied by impaired epithelial integrity, increased macrophage infiltration, and enhanced colon cancer risk.Methods and ResultsCannabidiol (CBD), a phytocannabinoid isolated from cannabis plants, is supplemented into mice diet, and its beneficial effects against dextran sulfate sodium (DSS)‐induced experimental colitis is evaluated. Eight‐week‐old mice were fed a standard diet supplemented with or without CBD (200 mg kg‐1) for 5 weeks. In the 4th week of dietary treatment, mice were subjected to 2.5% DSS induction for 7 days, followed by 7 days of recovery, to induce colitis. CBD supplementation reduced body weight loss, gross bleeding, fecal consistency, and disease activity index. In addition, CBD supplementation protected the colonic structure, promoted tissue recovery, and ameliorated macrophage infiltration in the colonic tissue, which was associated with the activation of cyclic AMP‐protein kinase A, extracellular signal‐regulated kinase ½, and AMP‐activated protein kinase signaling pathways. CBD supplementation also suppressed NLRP3 inflammasome activation and related pro‐inflammatory marker secretion. Consistently, CBD feeding reduced tight junction protein claudin2 and myosin light chain kinase in DSS‐treated mice.ConclusionDietary CBD protects against inflammation and colitis symptoms induced by DSS, providing an alternative approach to IBD management.

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Section: Discussionsupporting

confidence: 73%

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS‐Induced Colitis Mice

Sun,

Bravo Iniguez,

Tian

et al. 2024

Molecular Nutrition Food Res

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“…The activation of this signaling pathway is associated with downregulation of its inhibitor Phosphatase and tensin homolog (PTEN). Moreover, www.nature.com/scientificreports/ cancer cells had upregulated Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC1α), and B-cell lymphoma 2 (BCL2) that associated with down regulation of P53 that indicated cell proliferation and mitochondrial stress 28,29 . Extracellular signal-regulated kinase (Erk) activates PI3K-mTOR pathway 29 to promote tumorigenesis, angiogenesis and migration that are associated with inhibition of autophagy and apoptosis 30 .…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

Diab,

Tayea,

Elwakil

et al. 2024

Sci Rep

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The present work aimed to assess the potential effect of sericin/propolis/fluorouracil nanoformula against colorectal cancer (CRC) (the fourth most common cause of cancer-related mortalities). A novel anti-cancerous formula of the synthesized sericin/propolis nanoparticles was developed and tested both in vitro (using Caco-2 cell line) and in vivo (in experimentally induced colorectal cancer animal models). The combination index of the prepared nanoformula proved that the combination between sericin/propolis nanoparticles and 5-fluorouracil demonstrated the highest synergistic effect (0.86), with dose reduction index (DRI) of the chemotherapeutic drug reaching 1.49. The mechanism of action of the prepared nanoformula revealed that it acts through the inhibition of the PI3K/AKT/mTOR signaling pathway and consequently inhibiting cancerous cells proliferation. Treatment and prophylactic studies of both sericin and propolis showed increased TBARS (Thiobarbituric Acid Reactive Substance) formation, downregulated BCL2 (B-cell lymphoma 2) and activated BAX, Caspase 9 and Caspase 3 expression. The prepared nanoformula decreased the ROS (Reactive Oxygen Species) production in vivo owing to PI3K/AKT/mTOR pathway inhibition and FOXO-1 (Forkhead Box O1) activation that resulted in autophagy/apoptosis processes stimulation. The potent anticancer effect of the prepared nanoformula was further emphasized through the in vivo histopathological studies of experimentally induced tumors. The newly formulated sericin/propolis/fluorouracil nanoparticles exhibited clear-cut cytotoxic effects toward tumor cells with provided evidence for the prophylactic effect.

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“…11 Mitochondrial biogenesis is extensively required in cells with high energy demands, especially after differentiation from stem cells because stem cells normally contain minimal numbers of mitochondria. 12 It is to be mentioned that, although there are nearly 1200 proteins involved in building mitochondria, only 13 genes are transcribed from mtDNA 13 and mtDNA is used in phylogenetic studies because of its uniparental inheritance specifically from mother to child, 14 which means mtDNA is maternally transmitted. 15 The process of mitochondrial biogenesis is tightly regulated and depends on both mitochondrial and nuclear factors.…”

Section: Mitochondria-related Processesmentioning

confidence: 99%

“…Mitochondrial biogenesis is a process that increases the actual mass of mitochondrial networks as the process involves complete mtDNA replication, which is absent in mitochondrial fission . Mitochondrial biogenesis is extensively required in cells with high energy demands, especially after differentiation from stem cells because stem cells normally contain minimal numbers of mitochondria . It is to be mentioned that, although there are nearly 1200 proteins involved in building mitochondria, only 13 genes are transcribed from mtDNA and mtDNA is used in phylogenetic studies because of its uniparental inheritance specifically from mother to child, which means mtDNA is maternally transmitted …”

Section: Mitochondria-related Processesmentioning

confidence: 99%

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

Koh

Pan

2023

J. Agric. Food Chem.

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Mitochondrial dysfunction may cause cell death, which has recently emerged as a cancer prevention and treatment strategy mediated by chemotherapy drugs or phytochemicals. However, most existing drugs cannot target cancerous cells and may adversely affect normal cells via side effects. Mounting studies have revealed that phytochemicals such as resveratrol could ameliorate various diseases with dysfunctional or damaged mitochondria. For instance, resveratrol can regulate mitophagy, inhibit oxidative stress and preserve membrane potential, induce mitochondrial biogenesis, balance mitochondrial fusion and fission, and enhance the functionality of the electron transport chain. However, there are only a few studies suggesting that phytochemicals could potentially protect against the cytotoxicity of some current cancer drugs, especially those that damage mitochondria. Besides, COVID-19 and long COVID have also been reported to be correlated to mitochondrial dysfunction. Curcumin has been reported bringing a positive impact on COVID-19 and long COVID. Therefore, in this study, the benefits of resveratrol and curcumin to be applied for cancer treatment/prevention and disease amelioration were reviewed. Besides, this review also provides some perspectives on phytochemicals to be considered as a treatment adjuvant for COVID-19 and long COVID by targeting mitochondrial rescue. Hopefully, this review can provide new insight into disease treatment with phytochemicals targeting mitochondria.

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PGC-1α in mediating mitochondrial biogenesis and intestinal epithelial differentiation promoted by purple potato extract

Cited by 10 publications

References 58 publications

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS‐Induced Colitis Mice

Dietary Cannabidiol Activates PKA/AMPK Signaling and Attenuates Chronic Inflammation and Leaky Gut in DSS‐Induced Colitis Mice

In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

The Role of Mitochondria in Phytochemically Mediated Disease Amelioration

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