PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma

Savagner, Frédérique; Mirebeau, Delphine; Jacques, Caroline; Guyétant, Serge; Morgan, Catherine; Franc, Brigitte; Reynier, Pascal; Malthièry, Yves

doi:10.1016/j.bbrc.2003.09.076

Cited by 66 publications

(55 citation statements)

References 27 publications

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“…In addition, recent studies have reported a role of TFAM in oncogenesis. TFAM, which is increased in thyroid oncocytoma (Savagner et al, 2003), and mitochondrial DNA (mtDNA) depletion cause apoptosis in osteosarcoma cells (Dey and Moraes, 2000). Moreover, loss of the TFAM gene reduces tumorigenesis in an oncogenic Kras-driven mouse model of lung cancer (Weinberg et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

An Analogue of Resveratrol HS-1793 Exhibits Anticancer Activity Against MCF-7 Cells Via Inhibition of Mitochondrial Biogenesis Gene Expression

Jeong

Song

Kim

et al. 2012

Molecules and Cells

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Section: Discussionmentioning

confidence: 99%

An Analogue of Resveratrol HS-1793 Exhibits Anticancer Activity Against MCF-7 Cells Via Inhibition of Mitochondrial Biogenesis Gene Expression

Jeong

Song

Kim

et al. 2012

Molecules and Cells

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“…We choose to investigate the thyroid tumours on the basis of their various mitochondrial content, and, in particular, the thyroid oncocytoma, a mitochondrial-rich thyroid tumour characterised by an oxidative metabolism (Savagner et al, 2003;Baris et al, 2004). In oncocytoma, the large majority of the cells show extensive mitochondrial biogenesis; these tumours thereby constitute an interesting model for the study of the expression and localisation of DAP3, as well as its function in the mitochondrial ribosome.…”

mentioning

confidence: 99%

Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours

et al. 2009

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BACKGROUND: The human death-associated protein 3 (hDAP3) is a GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function. METHODS: A search through publicly available microarray data sets showed 337 genes potentially coregulated with the DAP3 gene. The promoter sequences of these 337 genes and 70 out of 85 mitochondrial ribosome genes were analysed in silico with the DAP3 gene promoter sequence. The mitochondrial role of DAP3 was also investigated in the thyroid tumours presenting various mitochondrial contents. RESULTS: The study revealed nine transcription factors presenting enriched motifs for these gene promoters, five of which are implicated in cellular growth (ELK1, ELK4, RUNX1, HOX11-CTF1, TAL1-ternary complex factor 3) and four in mitochondrial biogenesis (nuclear respiratory factor-1 (NRF-1), GABPA, PPARG-RXRA and estrogen-related receptor alpha (ESRRA)). An independent microarray data set showed the overexpression of ELK1, RUNX1 and ESRRA in the thyroid oncocytic tumours. Exploring the thyroid tumours, we found that DAP3 mRNA and protein expression is upregulated in tumours presenting a mitochondrial biogenesis compared with the normal tissue. ELK1 and ESRRA were also showed upregulated with DAP3. CONCLUSION: ELK1 and ESRRA may be considered as potential regulators of the DAP3 gene expression. DAP3 may participate in mitochondrial maintenance and play a role in the balance between mitochondrial homoeostasis and tumourigenesis.

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“…The combination of the two observed phenomena, loss of CK expression and NOS over-expression, both of which were known to promote mitochondrial biogenesis [13,25], also prompted us to investigate the status of mitochondrial biogenesis and the transcriptional cascade behind it in sarcoma. Mitochondrial biogenesis is well studied in different human and rodent systems, including in several forms of cancerous tissues [26,27]. Mitochondrial biogenesis is mainly characterized by an increased rate of mitochondrial DNA replication and transcription.…”

Section: Discussionmentioning

confidence: 99%

“…The process of mitochondrial biogenesis is well controlled by a set of transcription factors, and their strict co-ordination is well studied in various subjects, including in several forms of cancerous tissues [14,26,27]. Mitochondrial transcription factor A (mtTFA) regulates mtDNA replication and transcription, and it is found to be highly upregulated in sarcoma (Fig.…”

Section: Discussionmentioning

confidence: 99%

The transcriptional cascade associated with creatine kinase down-regulation and mitochondrial biogenesis in mice sarcoma

Bera

Ray

2009

Cellular and Molecular Biology Letters

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Abstract:The tissue-specific expressions of creatine kinase (CK) isoforms are regulated by the coordinated action of various transcription factors. The myogenic differentiation factor D (MyoD) family of proteins and the myocytespecific enhancer binding factor 2 family of transcription factors are important in regulating the muscle-specific expression of cytosolic muscle-type CK (MCK) and mitochondrial CKs. As reported in some related studies, TNF-α mediated degradation of MyoD and myogenin mRNA may lead to severe muscle wasting and cachexia, which is characterized by a low transcript level of MCK and myosin heavy chain proteins. In our previous study, we reported on a complete loss of total CK activity and expression when sarcoma was induced in mouse skeletal muscle (Patra et al. FEBS J. 275 (2008) 3236-3247). This study aimed at investigating the transcriptional cascade of CK down-regulation in carcinogen-induced sarcoma in mouse muscle. Both CK deficiency and enhanced nitric oxide synthase (NOS) were known to augment mitochondrial biogenesis, so we also explored the activation of the transcriptional cascade of mitochondrial biogenesis in this cancer. We observed the activation of the TNF-α-mediated nitric oxide production pathway with NFκB activation and concomitant degradation of MyoD and myogenin mRNA. Exploration of mitochondrial biogenesis revealed high cytochrome c oxidase activity and mitochondrial DNA content in sarcoma. The PGC-related co-activator seems to have a major role in regulating mitochondrial biogenesis by upregulating nuclear respiratory factors and mitochondrial transcription factor A. From the above findings, it can be concluded that severe muscle degeneration leads to CK downregulation in sarcoma, and that the stimulation of mitochondrial biogenesis indicated a scenario representing both CK deficiency and NOS overexpression on the one hand, and altered bioenergetic profiling on the other.

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PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma

Cited by 66 publications

References 27 publications

An Analogue of Resveratrol HS-1793 Exhibits Anticancer Activity Against MCF-7 Cells Via Inhibition of Mitochondrial Biogenesis Gene Expression

An Analogue of Resveratrol HS-1793 Exhibits Anticancer Activity Against MCF-7 Cells Via Inhibition of Mitochondrial Biogenesis Gene Expression

Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours

The transcriptional cascade associated with creatine kinase down-regulation and mitochondrial biogenesis in mice sarcoma

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