“…Regulators and substrates of His phosphorylation have been previously linked to roles in tumorigenesis (ACLY(Carrer et al, 2019; Shah et al, 2016), LHPP(Hou et al, 2020; Li et al, 2019; Sun et al, 2020; Wang et al, 2021; F. Wu et al, 2020; Zhang et al, 2020; Zheng et al, 2018), PGAM5(Cheng et al, 2018; Ng Kee Kwong et al, 2018)), and metastasis (ACLY(Wen et al, 2019), PHPT1(Xu et al, 2010), PGAM5(Kang et al, 2015), NME1(Kantor et al, 1993; Khan et al, 2019; Lee et al, 2018; Steeg et al, 1988; Suzuki et al, 2004)) and localize to varying subcellular regions, based upon data from this study and previous publications (detailed in Table 1). Analyzing these proteins and pHis signals in mouse pancreatic tumors, we found that pHis signals were decreased as compared to normal pancreatic tissue and non-tumor or stromal cells.…”