PFOS induced precocious hatching of Oryzias melastigma – From molecular level to individual level

Chronic Exposure of Marine Medaka (Oryzias melastigma) to 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) Reveals Its Mechanism of Action in Endocrine Disruption via the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis

“…28 However, transgenerational effects due to parental DCOIT exposure were imposed on medaka offspring and the capacity to produce viable offspring was reduced, as mainly manifested by a strong inhibition of hatching and reduced swimming activity ( Figure 6), both of which have been frequently used as sensitive indicators of offspring viability following exposure to toxins. 12,29,30 Previous research has shown that altered expression of the hatching enzyme choriolysin could be a major contributor to the abnormal hatching rate. 30 However, in the present study, no differential transcriptions of the two choriolysin enzymes were observed in the medaka embryo after DCOIT treatment.…”

“…12,29,30 Previous research has shown that altered expression of the hatching enzyme choriolysin could be a major contributor to the abnormal hatching rate. 30 However, in the present study, no differential transcriptions of the two choriolysin enzymes were observed in the medaka embryo after DCOIT treatment. In addition to the gradual hydrolysis of the chorion by choriolysin enzymes at the time of hatching, vigorous activity of medaka larvae inside the chorion is also a prerequisite to facilitate the ability of the larvae to rupture the hard eggshell.…”

Temperature-dependent physiological and biochemical responses of the marine medaka Oryzias melastigma with consideration of both low and high thermal extremes

“…The marine medaka Oryzias melastigma, which is a counterpart of the freshwater medaka O. latipes with genome data available, has been advocated to be a saltwater fish model for marine environmental research and ecotoxicological studies Wu et al, 2012). To date, most documented studies on O. melastigma concentrated on studying their pollutant-stress-induced transcriptional changes and acute toxicity responses (Bao et al, 2011;Fang et al, 2012).…”

Development of a Promising Fish Model (Oryzias melastigma) for Assessing Multiple Responses to Stresses in the Marine Environment

“…The marine biological toxicity of PFOS was systematically studied by Dong et al using O. melastigma [10, 23, 26–28]. Their results showed that exposure to PFOS could induce the hatching enzyme both at transcriptional and enzymatic activity levels and further lead to decreases of average hatching time and increases of the average hatchability of O. melastigma embryos, which in turn induced the mortality of the larvae hatched from exposed embryos.…”

“…There is an inverse correlation between the muscle water contents (MWC) and salinity in O. latipes ; however, the two parameters are not related in O. melastigma [7]. Exposure to perfluorooctane sulfonates (PFOS) shortened the hatching time and increased the hatching rate of O. melastigma but had the opposite effects in zebrafish [8–10]. These differences illustrate that ecotoxicological results from freshwater environments cannot be directly applied to the marine environment.…”