1996
DOI: 10.1016/0166-6851(96)02564-9
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PfKIN, an SNF1 type protein kinase of Plasmodium falciparum predominantly expressed in gametocytes

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Cited by 19 publications
(11 citation statements)
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“…Examples of such "orphan" kinases are (i) the cluster formed by PfKIN [PF140516], an enzyme previously described as related to the SNF1 family [42], with two uncharacterised PfPKs [PF14_0476 and PF13_0085]. This cluster is located at the base of the CamK and AGC branches, and does not strongly associate with any established ePK group (when mammalian NIM1/SNF1-like kinases were included in the phylogenetic tree no malarial kinases clustered with them (not shown)).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Examples of such "orphan" kinases are (i) the cluster formed by PfKIN [PF140516], an enzyme previously described as related to the SNF1 family [42], with two uncharacterised PfPKs [PF14_0476 and PF13_0085]. This cluster is located at the base of the CamK and AGC branches, and does not strongly associate with any established ePK group (when mammalian NIM1/SNF1-like kinases were included in the phylogenetic tree no malarial kinases clustered with them (not shown)).…”
Section: Resultsmentioning
confidence: 99%
“…Compilation of data from this study indicated that a small number of PfePKs are specific to gametocytes, including two of the NIMA-related kinases (one of which is potentially targeted to the apicoplast), one of the MAPKs (Pfmap-2), and PfKIN, an enzyme previously described as related to the SNF1 family (see above). Gametocyte-specific expression had been described in the literature for the latter two enzymes [42,45]. Overall, and despite some discrepancies, there is good agreement between the two studies with respect to PfePK genes, as illustrated by the observation that PfePKs whose expression is detected in late schizonts and segmenters by Bozdech et al are also detected in free merozoites by Le Roch et al At least some of these enzymes are likely to play a role in invasion of the erythrocyte by the merozoite.…”
Section: Resultsmentioning
confidence: 99%
“…Yeast SNF1 plays a role in transcriptional activation and repression to respond to several forms of stress such as nutrient limitation, salt stress and heat shock (reviewed in [47,48]). PfKIN is predominantly expressed in gametocytes [49], and accordingly reverse genetics in P. berghei indicates that the gene product is not required for the erythrocytic asexual cycle.…”
Section: The Camk Groupmentioning
confidence: 99%
“…KIN is a putative serine/threonine kinase, with limited homology to the conserved family of sucrose non-fermenting 1 (SNF1) and AMP-activated kinases (AMPK)4,14,17 that regulate cellular energy homeostasis in yeast and mammalian cells, respectively18,19. AMPK/SNF1 is a heterotrimeric complex comprising a α-catalytic subunit and two regulatory subunits β and γ.…”
mentioning
confidence: 99%