Pfaffia paniculata (Brazilian ginseng) methanolic extract reduces angiogenesis in mice

Biochemical Basis and Therapeutic Implications of Angiogenesis

“…Similar health benefi ts may also be attained by peripheral arterial disease patients, which is a population characterized with ischemia of the limbs that often leads to tissue necrosis requiring amputation [ 164 ]. Notably, chronic exercise training consisting of 50 min of walking exercise at an intensity below that which induces claudication symptoms twice a week for 6 months signifi cantly elevated EPCs and VEGF in patients diagnosed with peripheral artery disease [ 135 ]. Moreover, exercise-induced angiogenesis may have an important therapeutic role in heart failure.…”

“…We found that TGFβ was able to downregulate the expression of VEGFR2 in colorectal tumor vasculature in an Alk5/Smad2-dependent fashion [ 58 ]. VEGFR2 expression on glioma blood vessels increased with tumor progression, and the proportion of p-Smad2-positive endothelial cells was signifi cantly higher in tumor vessels compared to normal brain vasculature [ 135 ]. There is evidence that ALK1 signaling in cancer angiogenesis may modulate cross talk between EC and pericytes, and inhibition of ALK1 may be especially effective in VEGF refractory tumors [ 128 ].…”

“…Interestingly, ASC showed an upregulation and co-expression of VEGF, bFGF, and SDF-1α [ 94 ]. SDF-1α/CXCR4/SDF-1α receptor interaction has shown to induce a rapid and effective mobilization of stem/progenitor cells from bone marrow [ 135 ] and to be essential for organ system vascularization [ 136 ]. Altogether, these data suggest a cooperative effect of transplanted ASC with endogenous BM-derived stem/progenitors via an SDF-1α-dependent cell homing mechanism likely promoting angio/vasculogenesis in the ischemic myocardium [ 94 ].…”

Inhibition of ascitic ehrlich tumor cell growth by intraperitoneal injection of Pfaffia paniculata (Brazilian ginseng) butanolic residue

“…Previous studies have shown that the Brazilian ginseng, P. paniculata, presents both antineoplastic (Matsuzaki et al 2003, Matsuzaki et al, 2006, Carneiro et al, 2007, Nagamine et al, 2008 and cancer chemopreventive properties (Silva et al, 2005). The whole powdered root presented antineoplastic effects against Ehrlich ascites tumor (Matsuzaki et al 2003), and chemopreventive activity in a mouse hepatocarcinogenesis model (Silva et al, 2005).…”

“…The whole powdered root presented antineoplastic effects against Ehrlich ascites tumor (Matsuzaki et al 2003), and chemopreventive activity in a mouse hepatocarcinogenesis model (Silva et al, 2005). The methanolic extract of P.paniculata decreased the angiogenesis in the mouse cornea model (Carneiro et al, 2007), indicating a possible antiproliferative effect. The oral administration of the butanolic residue presented inhibitory effects on Ehrlich tumor bearing mice, increasing the survival time (Matsuzaki et al, 2006) and also antineoplastic effects on mammary tumor cells MCF7 (Nagamine et al, 2008).…”