Pf744 Spectrum of Parvovirus B19 Infection in Children With Sickle Cell Disease: Atypical Presentations

Abstract

Conclusion: While the majority of our patients were prescribed antibiotic prophylaxis, due to non-compliance, only half of our cohort were taking antibiotics reliably. There were few culture positive cases of infection, indicating that adults with SCD are at lower risk of infection compared with children, consistent with the literature [3]. In our cohort, over the 3 year period, there was only 1 documented case of pneumococcal disease. The low incidence of infection may have been due to our cohort being of younger age, with few comorbidities and a relatively high proportion of lower risk genotype. This work highlights the need for prospective, randomised evidence in SCD patients to establish whether a benefit exists for pneumococcal prophylaxis in adulthood. [1]