Abstract:Background:Diffuse large B‐cell lymphoma (DLBCL), though highly curable with immunochemotherapy, is a heterogenous group of diseases that include subsets of tumors with different cells of origin (COO). Using gene‐expression profiling, DLBCLs can be categorized into 2 clinically distinct subgroups, namely activated B‐cell (ABC) and germinal center B‐cell (GCB). More recently, double‐expressor (DEL) or double‐hit lymphoma (DHL) was described as a new form of aggressive lymphoma based on the expression or re‐arra… Show more
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