Pf508 Autochthonous Mouse Models of MYD88 P.L265P ‐ and Bcl2‐driven Diffuse Large B Cell Lymphoma

Abstract

to the absence of anemia (compensated hemolytic anemia) and the increase of hepcidine could be explained by the high ferritin levels. In the ineffective erythropoiesis group, despite the anemia, no statistically significant ERFE-hepcidin levels were observed. In splenectomized HS patients, ERFE/hepcidine levels were similar to those of the control group. The newly identified ERFE hormone may act as physiological hepcidin suppressor in cases with IDA, but we have to establish this relationship in other types of anemia, for which it is necessary to evaluate more patients. The high number of patients that we had to exclude due to ERFE results outside the assay sensitivity range implies the need of validation and standardization of the method.