1995
DOI: 10.1006/bbrc.1995.1591
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Pez - A Novel Human cDNA Encoding Protein Tyrosine Phosphatase- and Ezrin-Like Domains

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Cited by 54 publications
(51 citation statements)
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“…T he protein tyrosine phosphatase Pez is the Drosophila homologue of non-receptor type protein tyrosine phosphatase 14 (PTPN14), a regulator of the TGF-b pathway [1][2][3] . PTPN14 overexpression activates TGF-b signalling and causes epithelial-mesenchymal transition (EMT) 2 .…”
mentioning
confidence: 99%
“…T he protein tyrosine phosphatase Pez is the Drosophila homologue of non-receptor type protein tyrosine phosphatase 14 (PTPN14), a regulator of the TGF-b pathway [1][2][3] . PTPN14 overexpression activates TGF-b signalling and causes epithelial-mesenchymal transition (EMT) 2 .…”
mentioning
confidence: 99%
“…The PTPN14 transcript is processed into a mature mRNA in excess of 10 kb, estimated by Northern blot analysis (Smith et al, 1995). The mature transcript has a 3561 nucleotide open reading frame and ~9,2 kb 3' UTR followed by a polyadenylation site.…”
Section: Transcriptionmentioning
confidence: 99%
“…It possesses an N-terminal FERM (band 4.1, ezrin, radixin, moesin homology) domain and C-terminal catalytic domain, as well as acidic and proline-rich regions in its central uncharacterised region (Smith et al, 1995). FERM domain: the FERM domain has been shown in other proteins to be important for cytoskeletal association; however a role for the FERM domain in the PTPN14 protein has yet to be described.…”
Section: Descriptionmentioning
confidence: 99%
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“…Pez is a non-receptor protein tyrosine phosphatase (PTP), 1 which has until recently remained fairly poorly characterised in terms of elucidation of a defined cellular function. Pez (also known as PTPD2 2 and PTPN14, 3 in human and PTP36 in the mouse 4 has been found to localise to multiple sub-cellular locations, depending on factors such as cell type, cell-matrix adhesion, 4 serine phosphorylation 5 and cell confluency, 6 suggesting differential regulation of Pez function in alternative cell states and cellular contexts.…”
Section: Introductionmentioning
confidence: 99%