Peyronie’s Disease: Treatment by the Local Injection of Meticortelone and Hydrocortisone

Furey, Clement A.

doi:10.1016/s0022-5347(17)66550-9

Cited by 39 publications

(8 citation statements)

References 8 publications

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“…Although six studies using injectable corticosteroids for the treatment of PD showed positive outcomes from treatment, the authors believe that the therapeutic effects were because of the mechanical effects of the injection and not to the drug action itself [125][126][127][128][129][130][131].…”

Section: Intralesional Injections Steroidsmentioning

confidence: 99%

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

Ralph,

Gonzalez-Cadavid,

Mirone

et al. 2010

The Journal of Sexual Medicine

315

437

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Introduction The field of Peyronie’s disease is evolving and there is need for a state-of-the-art information in this area. Aim To develop an evidence-based state-of-the-art consensus report on the management of Peyronie’s disease. Methods To provide state-of-the-art knowledge regarding the prevalence, etiology, medical and surgical management of Peyronie’s Disease, representing the opinion of leading experts developed in a consensus process over a 2-year period. Main Outcome Measures Expert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. Conclusions The real etiology of Peyronie’s disease and the mechanisms of formation of the plaque still remain obscure. Although conservative management is obtaining a progressively larger consensus among the experts, surgical correction still remains the mainstay treatment for this condition.

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Section: Intralesional Injections Steroidsmentioning

confidence: 99%

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

Ralph,

Gonzalez-Cadavid,

Mirone

et al. 2010

The Journal of Sexual Medicine

315

437

View full text Add to dashboard Cite

show abstract

“…Furey [8] first suggested that sexual trauma is the major cause of Peyronie's disease in 1957. This theory since has Peyronie's disease is an acquired condition that presents clinically with a palpable induration, a distinct plaque, or a curvature of the erect penis.…”

Section: Pathophysiologymentioning

confidence: 99%

Conservative management options for peyronie’s disease

Jack¹,

González‐Cadavid²,

Rajfer

2005

Curr Urol Rep

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Peyronie's disease is an acquired condition that presents clinically with a palpable induration, a distinct plaque, or a curvature of the erect penis. At times, the erections are painful. Erectile dysfunction (ED) often is associated with Peyronie's disease. The current era of phosphodiesterase therapy for the treatment of ED seems to have increased the number of patients presenting for treatment of Peyronie's disease. During the past decade, significant advances have been made in understanding the pathophysiology of the disease, resulting in numerous nonsurgical therapies proposed for the treatment of Peyronie's disease. These medical treatments can be administered systemically, locally, or intralesionally. Unfortunately, there are few randomized, placebo-controlled trials to evaluate most of these proposed therapies. In evaluating therapies for Peyronie's disease, it must be remembered that the natural disease history includes spontaneous resolution of pain and even a small improvement in penile curvature in some men. This article reviews the natural history, scientific understanding, and nonsurgical treatment options for the mild to moderate Peyronie's deformities. Surgical therapy remains the mainstay of treatment for severe and refractory cases of Peyronie's disease that result in a physical or psychologic dysfunction.

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“…In 1957, Furey [10] suggested that minor trauma is the cause of PD and a 1997 survey of 732 patients demonstrated an association between penile trauma and PD and ED [11]. Devine et al [12] have proposed a detailed model of trauma as the cause of the Peyronie's plaque with its excessive collagen, abnormal fibrin, and disordered elastic fibers.…”

Section: Natural Historymentioning

confidence: 99%

New discoveries in the basic science understanding of Peyronie’s disease

Jalkut¹,

González‐Cadavid²,

Rajfer

2004

Curr Urol Rep

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Peyronie's disease is an acquired benign condition representing localized fibrosis of the penis. The disease is caused by microvascular trauma to the penis, with subsequent fibrin deposition resulting in aberrant wound healing and possibly other etiologies. Histopathologic studies of the Peyronie's plaque have demonstrated the role of transforming growth factor-beta 1 in the pathologic development of penile plaque. Animal models have been developed to test pathophysiology and therapeutics. The role of inducible nitric oxide synthase and nitric oxide has been established to limit and counteract fibrosis. Differential gene expression studies have identified candidate up-regulated or down-regulated genes that are involved in the pathophysiology of Peyronie's disease.

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Peyronie’s Disease: Treatment by the Local Injection of Meticortelone and Hydrocortisone

Cited by 39 publications

References 8 publications

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

Conservative management options for peyronie’s disease

New discoveries in the basic science understanding of Peyronie’s disease

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