Peyronie’s disease may negatively impact the sexual experience of a couple and female sexual function: a single center study

Illiano, Ester; Trama, Francesco; Mancini, Vito; Ruffo, A; Riezzo, Giuseppe; Riccardo, Filippo; Fabi, Consuelo; Carrieri, Giuseppe; Crocetto, Felice; Iacono, Fabrizio

doi:10.21037/tau-20-1067

Cited by 7 publications

(10 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PD presents with concomitant erectile dysfunction (ED) in 40-50% of men. The physical manifestations of PD contribute to the development of emotional distress and relationship problems (4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Intralesional collagenase Clostridium histolyticum for acute phase Peyronie’s disease: a single-center, retrospective cohort study

Hu¹,

Sigalos²,

Walker³

et al. 2022

Transl Androl Urol

View full text Add to dashboard Cite

Background: Peyronie's disease (PD) can be subdivided into acute and chronic phases. Intralesional collagenase Clostridium histolyticum has been shown to improve curvature in the chronic phase. Initial clinical trials excluded patients in the acute phase from treatment. Recent studies show comparable results among men in the acute phase. The definition of acute phase varies among existing studies, but it is generally understood to last 12-18 months and is accompanied by penile pain and progression of deformity. We sought to evaluate the safety and efficacy of intralesional collagenase injection therapy during the acute phase of PD using multiple definitions of the acute phase.Methods: All men receiving intralesional collagenase for PD from October 2015 through December 2020 at a single academic institution were retrospectively assessed for patient demographics and comorbidities, pre-and post-treatment curvature, and adverse events. Two definitions of acute phase were used: (I) acute phase duration ≤6 months, chronic phase duration >6 months; and (II) acute phase duration ≤12 months with penile pain, chronic phase duration >12 or no penile pain.Results: Of 330 patients identified, 229 underwent intralesional collagenase treatment with pre-and post-treatment erect penile goniometry. 65 (28%) met criteria for definition 1 of acute phase, 37 (16%) met criteria for definition 2, and 76 (33%) met criteria for either. Percent change in penile curvature was not significantly different between acute and chronic phases using definition 1 (16.0% vs. 16.6%, P=0.89), definition 2 (19.9% vs. 15.7%, P=0.43), or either (16.5% vs. 16.3%, P=0.96). The rates of development of bruising, swelling, hematoma, or corporal rupture were not significantly different between the acute and chronic phases under either definition (all P>0.05).Conclusions: This single-center, retrospective cohort analysis suggests that intralesional collagenase is both safe and effective for the treatment of men with acute phase PD. Limitations exist inherent to retrospective review, since many men did not return for post-treatment goniometry, possibly skewing our cohort toward incomplete responders. Prospective, randomized studies will be required to confirm these findings.

show abstract

Section: Introductionmentioning

confidence: 99%

Intralesional collagenase Clostridium histolyticum for acute phase Peyronie’s disease: a single-center, retrospective cohort study

Hu¹,

Sigalos²,

Walker³

et al. 2022

Transl Androl Urol

View full text Add to dashboard Cite

show abstract

“…Our study had shown that the sexual function of female partners was significantly improved compared to baseline especially desire, arousal, orgasm, and overall satisfaction except some of their sexual functions including frequency of satisfaction with arousal, frequency of lubrication, difficulty of becoming lubricated, and finally maintenance of lubrication that were not positively impacted which implies treating their male partners. Similarly, Illiano et al 22 had demonstrated that a viable approach to treatment of Peyronie's disease patients that included their partners could lead to better functional and psychological results in both of them. Remarkably, the low scores of the female partners in our study can be a subjective experience of sexual well-being rather than distress as they were healthy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the sexual function of female partners of men with erectile dysfunction receiving different treatment modalities: An observational study

et al. 2022

View full text Add to dashboard Cite

Objective: To evaluate sexual functions of patients with erectile dysfunction (ED) and their female partners. Methods: A total of 90 consecutive ED patients who received different ED therapies and their partners and 90 consecutive controls and their partners were divided into four groups. All participants were evaluated by the 15-item international index of erectile function and the Arabic version of female sexual function index (Ar-FSFI). Results: All ED patients who received sildenafil demonstrated significant improvements of their erectile function compared to baseline. Their partners did not demonstrate improvements in frequency of pain during vaginal penetration (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), confidence of becoming aroused (3.86 ± 0.58, 3.93 ± 0.45, p 0.477), frequency of satisfaction with arousal (3.07 ± 0.37, 3.03 ± 0.49, p 0.712), and maintenance of lubrication (4.37 ± 0.49, 4.23 ± 0.73, p 0.354). All ED patients who received quadmix demonstrated significant improvements of their erectile function compared to baseline. Their partners did not demonstrate improvements in desire level (2.6 ± 0.67, 2.63 ± 0.85, p = 0.869) and lubrication maintenance (3.53 ± 0.82, 3.47 ± 0.82, p = 0.423). Finally, All ED patients who underwent semi rigid penile implant demonstrated significant improvements of their erectile function compared to baseline. Their female partners demonstrated significant improvements in all items of FSFI-19 compared to baseline except the frequency of pain during vaginal penetration (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), confidence of becoming aroused (3.86 ± 0.58, 3.93 ± 0.45, p = 0.477), frequency of satisfaction with arousal (3.07 ± 0.37, 3.03 ± 0.49, p = 0.712), and maintenance of lubrication (4.37 ± 0.49, 4.23 ± 0.73, p = 0.354). Conclusions: Sexual functions of ED males significantly improved after ED therapies. Nevertheless, some sexual functions of their partners were not positively impacted.

show abstract

“…PD occurs in 3.2% to 8.9% of the male population, and it typically presents at 55 to 60 years of age; however, it can occur at any age [ 6 , 7 ]. Traditionally, men with PD experience pain during sexual intercourse, erectile dysfunction, and emotional and physical distress [ 8 ]. Furthermore, erectile dysfunction caused by pathological disease progression greatly affects the sexual activity of men and their partner [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, men with PD experience pain during sexual intercourse, erectile dysfunction, and emotional and physical distress [ 8 ]. Furthermore, erectile dysfunction caused by pathological disease progression greatly affects the sexual activity of men and their partner [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Use of penile shear wave elastosonography for the diagnosis of Peyronie’s Disease: a prospective case–control study

Trama

Illiano

Iacono

et al. 2022

Basic Clin. Androl.

Self Cite

View full text Add to dashboard Cite

Background To evaluate the stiffness of the tunica albuginea (TA), we used a new noninvasive diagnostic technique called shear wave elastography (SWE). We determined whether SWE values are correlated with the degree of penile curvature, the time of disease onset, and pain severity experienced by patients during erection. This study analyzed the elasticity of the TA of patients with Peyronie’s disease compared to that of the control group. We also analyzed any correlations between the stiffness of the cavernous bodies and the degree of curvature, time from diagnosis to curvature onset, and erectile pain severity. This was a prospective case–control study involving 100 men enrolled from September 2020 to August 2021. Participants were divided into group A (case group, n = 50), which included men with PD, with or without pain, and with penile curvature, or group B (control group, n = 50), which included healthy patients older than 18 years who visited the urology clinic for reasons other than PD. The medical history was collected for all patients who also underwent objective examination, B-mode ultrasound evaluation, and SWE. The International Index of Erectile Function (IIEF-15) visual analog scale (VAS) questionnaire was administered to all participants. Results There were no significant between-group differences regarding age, weight, and height (p > 0.05); however, there was a significant difference in the stiffness values (p < 0.05). An inverse correlation was observed between stiffness and the VAS score (p < 0.0001). A positive correlation was observed between the degree of curvature (p < 0.0001) and the time of curvature onset (p < 0.0001). The IIEF-15 scores were poorer in group A than in group B (p < 0.0001). Conclusion SWE is an inexpensive, noninvasive method that can be used to measure the stiffness of PD patients.

show abstract

Peyronie’s disease may negatively impact the sexual experience of a couple and female sexual function: a single center study

Cited by 7 publications

References 36 publications

Intralesional collagenase Clostridium histolyticum for acute phase Peyronie’s disease: a single-center, retrospective cohort study

Intralesional collagenase Clostridium histolyticum for acute phase Peyronie’s disease: a single-center, retrospective cohort study

Evaluation of the sexual function of female partners of men with erectile dysfunction receiving different treatment modalities: An observational study

Use of penile shear wave elastosonography for the diagnosis of Peyronie’s Disease: a prospective case–control study

Contact Info

Product

Resources

About