Peyronie’s Disease and Erectile Failure

Metz, P; Ebbehøj, J; Uhrenholdt, A; Wagner, Gorm

doi:10.1016/s0022-5347(17)51706-1

Cited by 64 publications

(25 citation statements)

References 7 publications

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“…23 Metz et al showed abnormal venous drainage in 69% of Peyronie's patients with ED using dynamic Xenon washout and stated that VOD was primarily responsible for ED. 24 Gasior et al reported their results of DICC in Peyronie's patients with ED and found that 86% had evidence of VOD. 25 However, Lopez and Jarow were the ®rst to show that the high prevalence of VOD was unique to Peyronie's disease.…”

Section: Discussionmentioning

confidence: 99%

Color Doppler ultrasound assessment of penile vascular system in men with Peyronie's disease

et al. 2000

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The purpose of this study was to evaluate the penile vascular function by color Doppler ultrasonography (CDU) in patients with Peyronie's disease. A total of 136 men with Peyronie's disease were strati®ed according to their potency by history as Group I consisting of potent patients and Group II consisting of patients with erectile dysfunction. They were all evaluated by penile CDU.Overall, 70.6% had erectile dysfunction by history. CDU revealed penile vascular abnormalities in 76.5%. In Group I, veno-occlusive dysfunction (VOD) was observed in 40% while mixed (arterial venous) vascular disease was diagnosed in 10%. Penile vascular disease was detected in 87.5% patients in Group II (ie VOD in 28%, arterial disease in 9.3% and mixed vascular disease in 50%). The prevalence of arterial disease on CDU among Peyronie' patients with erectile dysfunction (59.3%) was signi®cantly (P`0.05) higher then it was among potent patients (10%). The prevalence of pure VOD was almost similar for patients with or without erectile dysfunction (P`0.05).We conclude that penile vascular abnormalities can be observed in 76.5% on cases with Peyronie's disease by CDU and this ratio signi®cantly increases to 87.5% among cases with erectile dysfunction by history. Our data also indicate that arterial disease, accounts for much of the diminished rigidity in men with Peyronie's disease.

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Section: Discussionmentioning

confidence: 99%

Color Doppler ultrasound assessment of penile vascular system in men with Peyronie's disease

et al. 2000

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“…Quantitative and qualitative alterations in the collagen post-fixed in 2% osmium tetroxide, dehydrated in graded ethanol and propylene oxide, and embedded in Epon and elastic fibres may render the tunica unable to compress the subtunical and emissary veins adequately, 812. Randomized tissue blocks from patients with and without Peyronie's disease were thick-sectioned (1 mm) resulting in veno-occlusive dysfunction [16][17][18].…”

mentioning

confidence: 99%

Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence

Akkuş

Carrier

Baba

et al. 1997

British Journal of Urology

123

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Objective To investigate whether changes in the structure of the tunica albuginea influence the development of erectile dysfunction. Patients and methods Biopsy specimens taken from the tunica of 64 patients (both potent and impotent) with and without Peyronie's disease were evaluated. Tissue samples were stained and examined under light and electron microscopy, and the concentration of elastic fibres present in each was measured using computerized image analysis. Results The concentration of elastic fibres was lower in impotent than in potent patients (P=0.0365) and was also significantly less in patients with Peyronie's disease. Furthermore, the concentration of elastic fibres decreased with age. Electron and light microscopy revealed the presence of distinct alterations in the tunica albuginea in impotent patients and patients with Peyronie's disease that might interfere with function. Conclusion The decrease in elastic fibre concentration and changes in microscopic features may contribute to erectile dysfunction by impairing the veno‐occlusive function of the tunica albuginea.

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“…During detumescence, blood¯ow was initially elevated (20±75 mla100 gamin), and subsequently decreased to the¯accid levels 2.5±4 min after termination of the visual stimulation. In 1983, this group published results of intracavernosal injection of xenon in patients with Peyronie's disease, 31 a disorder which is frequently accompanied by erectile dysfunction. In ®ve patients with normal erectile function, normal venous closure was noted after onset of erection, similar to the ®nding previously noted in controls.…”

Section: Historical Development and Resultsmentioning

confidence: 99%

Use of radioactive tracers in the evaluation of penile hemodynamics: history, methodology and measurements

Zuckier

1997

Int J Impot Res

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Radionuclide tracer techniques are intimately associated with some of the early ground-breaking investigations in erectile dysfunction and have evolved along with the ®eld. At the present time, the various investigations can be grouped into four categories: labeled blood-pool; tracer washout; tracer washin and combined blood-poolatracer and tracer washout examinations. Blood pool studies are most useful in assessing the integrity of arterial in¯ow, but may also be used to generate indices of venous leak. A non-imaging version of the blood-pool test may represent a simple and cost-effective alternative. Washout of intracavernosal xenon during erection seems the most rigorous method of testing venous integrity. Washout using 99m Tc-labeled substances may emerge as a convenient alternative to the more technically dif®cult xenon examinations. Dual-isotope blood pool and washout examinations, though complicated, represent an ideal method of analyzing penile hemodynamics, with potential to contribute signi®cantly to the understanding of penile physiology. Development of improved pharmacologic stimuli and augmentation of testing protocols by intracavernosal pressure monitoring may further improve the utility of quantitative and physiologic nuclear medicine examinations in erectile dysfunction.

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Peyronie’s Disease and Erectile Failure

Cited by 64 publications

References 7 publications

Color Doppler ultrasound assessment of penile vascular system in men with Peyronie's disease

Color Doppler ultrasound assessment of penile vascular system in men with Peyronie's disease

Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence

Use of radioactive tracers in the evaluation of penile hemodynamics: history, methodology and measurements

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