Peucedanum japonicum Thunb (PJT) Extracts Enhance Adiponectin Secretion in Human Metabolic Stem Cells Screening System and in Healthy Individuals

Abstract

Adiponectin is an adipocyte specific-secreted protein playing a major role in regulating insulin sensitivity and lipid metabolism. Peucedanum japonicum Thunb (PJT) grown on the cliff of Tokunoshima Island in Japan contains rich polyphenolic compounds and exerts hypolipidemic properties. In this study we studied the efficacy of PJT on the adiponectin secretion in the adipocytes differentiated from human Metabolic Stem Cells (MSC) and in healthy individuals. Three types of PJT extracts of each (water, 50% ethanol, 100% ethanol extracts), rutin, or chlorogenic acid as phytochemical candidates of the PJT extracts was dropped directly onto the differentiated adipocytes from MSC of obese patients at day 8 and adiponectin levels in the culture medium were measured at day 10 and 12. The efficacy of PJT on adiponectin secretion (1260 mg/day for 3 months) was examined for 46 healthy individuals in an open labeledpreliminary study. Chlorogenic acid and rutin showed that they had more positive effects on adiponectin secretion than PJT extracts. In the study of healthy individuals, serum adiponectin levels of the elder individuals significantly increased after the trial. PJT extracts might have an adiponectin secretion-enhancing properties, attributing partly to rutin and chlorogenic acid.

Effect of Peucedanum japonicum Thunb on Body Composition and Biochemical Examination of Blood

“…The ingredients that are thought to be involved are chlorogenic acid, which is a polyphenol, and pteryxin, which is a coumarin compound. For chlorogenic acid, its inhibitory effect on obesity 11,12) and promotion effect of adiponectin secretion 13) have been reported. In addition, an anti-obesity effect of pteryxin has been shown by a fundamental experiment 8) .…”