Petrosynol and petrosolic acid, two novel natural inhibitors of the reverse transcriptase of human immunodeficiency virus from petrosia sp.

Isaacs, S.; Kashman, Yoel; Loya, Shoshana; Hizi, Amnon; Loya, Yossi

doi:10.1016/s0040-4020(01)80571-8

Cited by 67 publications

(92 citation statements)

References 15 publications

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“…This structure is strongly suggestive of a dimerization of two identical lipids that have the same half-chain length as the unoxygenated segments of petrocortynes A and B. Petrosynol (31R), which also a symmetric metabolite, and petrosolic acid (31S) have been isolated from a Red Sea Petrosia sp. [348]. Petrosolic acid is notable because C 44 carboxylic acids are relatively rare and it inhibited DNA polymerase activity of HIV reverse transcriptase.…”

Section: Marine Fatty Acids Andmentioning

confidence: 99%

Biosynthesis and function of polyacetylenes and allied natural products

Minto

Blacklock

2008

Progress in Lipid Research

291

228

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Polyacetylenic natural products are a substantial class of often unstable compounds containing a unique carbon-carbon triple bond functionality, that are intriguing for their wide variety of biochemical and ecological functions, economic potential, and surprising mode of biosynthesis. Isotopic tracer experiments between 1960 and 1990 demonstrated that the majority of these compounds are derived from fatty acid and polyketide precursors. During the past decade, research into the metabolism of polyacetylenes has swiftly advanced, driven by the cloning of the first genes responsible for polyacetylene biosynthesis in plants, moss, fungi, and actinomycetes, and the initial characterization of the gene products.The current state of knowledge of the biochemistry and molecular genetics of polyacetylenic secondary metabolic pathways will be presented together with an up-to-date survey of new terrestrial and marine natural products, their known biological activities, and a discussion of their likely metabolic origins.

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Section: Marine Fatty Acids Andmentioning

confidence: 99%

Biosynthesis and function of polyacetylenes and allied natural products

Minto

Blacklock

2008

Progress in Lipid Research

291

228

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“…inhibited reverse transcriptase of HIV virus (307,308). The sponge Strongylophora durissima yielded two new acetylenic derivatives, durissimols A and B (213), and duryne (214) (309-311).…”

Section: Marine and Freshwater Sponges (Porifera)mentioning

confidence: 99%

Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

127

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This review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. Although acetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities only for more than 300 acetylenic lipids and their derivatives isolated from living organisms.

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“…Both inhibited the DNA polymerase activities of the reverse transcriptase of human immunodeficiency virus. 101 Colpol (301), a dibromo C6-C4-C6 metabolite, was isolated from the Red Sea alga Colpomenia sinuosa. 102 A hydroxy phenyl heptadienoic acid, 3-hydroxy-7-phenyl-4E,6E-heptadienoic acid (302), had been obtained from the ascidian Didemnum granulatum collected from the Gulf of Eilat in the Red Sea.…”

Section: Other Metabolitesmentioning

confidence: 99%

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2017

IJPSR

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Petrosynol and petrosolic acid, two novel natural inhibitors of the reverse transcriptase of human immunodeficiency virus from petrosia sp.

Cited by 67 publications

References 15 publications

Biosynthesis and function of polyacetylenes and allied natural products

Biosynthesis and function of polyacetylenes and allied natural products

Anticancer activity of natural and synthetic acetylenic lipids

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