The adiabatic bulk (KS) and shear (G) moduli of mantle materials at high pressure and temperature can be obtained directly by measuring compressional and shear wave velocities in the laboratory with experimental techniques based on physical acoustics. We present the application of the current state-of-the-art experimental techniques by using ultrasonic interferometry in conjunction with synchrotron x radiation to study the elasticity of olivine and pyroxenes and their high-pressure phases. By using these updated thermoelasticity data for these phases, velocity and density profiles for a pyrolite model are constructed and compared with radial seismic models. We conclude that pyrolite provides an adequate explanation of the major seismic discontinuities at 410-and 660-km depths, the gradient in the transition zone, as well as the velocities in the lower mantle, if the uncertainties in the modeling and the variations in different seismic models are considered. The characteristics of the seismic scaling factors in response to thermal anomalies suggest that anticorrelations between bulk sound and shear wave velocities, as well as the large positive density anomalies observed in the lower mantle, cannot be explained fully without invoking chemical variations.elasticity ͉ mantle composition ͉ mantle heterogeneity ͉ ultrasonic interferometry ͉ pyrolite S eismological investigations provide the primary source of information about the properties and processes of the Earth's interior, especially for depths greater than a few hundreds of kilometers (i.e., depths below which rock samples have not yet reached the Earth's surface). In addition to regional studies that provide detailed velocity structures of the upper mantle and the transition zone, global Earth models of velocity and density profiles versus depths have been generated by compiling thousands of seismic records and data of different types, e.g., the Preliminary Earth Reference Model (1) and AK135 (2). The variations of compressional wave (P wave) and shear wave (S wave) wave velocities and densities in these models presumably reflect radial and lateral variations of chemical composition, mineralogy, pressure, and temperature. Successful interpretation of these seismic models in terms of the variables above requires experimental and theoretical information on the elasticity of Earth materials under the elevated conditions that characterize the Earth's interior. One of the petrological models that has been tested extensively in the literature is that of pyrolite, which was proposed by Ringwood (3) based on the compositions of mantle peridotites and oceanic basalts (4-8).We use the pyrolite model to compare with seismic models of both global and regional nature.Over the past 40 years or so, the elastic properties of many mantle minerals as well as their high-pressure phases have been studied by using static and shock compression and various spectroscopic techniques. Such approaches provide important information about the variation of density (hence compressibility) ...