Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker

Buzsáki, György; Smith, Alexander; Berger, Sebastian; Fisher, Lisa J.; Gage, Fred H.; Aston‐Jones, Gary; Bloom, Floyd E.

doi:10.1016/0306-4522(90)90345-5

Cited by 209 publications

(102 citation statements)

References 89 publications

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“…This thalamocortical loop model is consistent with a number of experimental results on SW epilepsy: (1) thalamic and cortical neurons discharge in synchrony during the spike, whereas the wave is characterized by neuronal silence (Pollen, 1964;Steriade, 1974;Avoli et al, 1983;McLachlan et al, 1984;Buzsáki et al, 1990;Inoue et al, 1993), similar to the data in Figures 4 E and 8 A; (2) TC cell firing precedes that of other cell types, followed by cortical cells and RE cells (Inoue et al, 1993), similar to the phase relations of the present model (see Fig. 8 B); (3) SW patterns disappear after the removal of either the cortex (Avoli and Gloor, 1982) or the thalamus Vergnes and Marescaux, 1992), as also predicted by the present mechanism; (4) antagonizing thalamic GABA B receptors suppresses SW discharges (Liu et al, 1992), consistent with this model; (5) spindle oscillations can be transformed gradually into SW discharges (Kostopoulos et al, 1981a,b), as described in Figure 6.…”

Section: Similarities With Experimental Models Of Spike and Wavesupporting

confidence: 89%

“…During the spike all cells fired prolonged high-frequency discharges in synchrony, whereas the wave was coincident with neuronal silence in all cell types. This portrait is typical of experimental recordings of cortical and thalamic cells during SW patterns (Pollen, 1964;Steriade, 1974;Avoli et al, 1983;McLachlan et al, 1984;Buzsáki et al, 1990;Inoue et al, 1993). Some TC cells stayed hyperpolarized during the entire oscillation (second TC cell in Fig.…”

Section: Suppression Of Intracortical Gaba a -Mediated Inhibition Leasupporting

confidence: 55%

“…Initially suggested by Jasper and Kershman (1941), the possible involvement of the thalamus in SW seizures was shown by recordings of thalamic nuclei in humans during absence attacks (Williams, 1953;Prevett et al, 1995). An important role for the thalamus also is supported by electrophysiological recordings in experimental models of SW seizures, which show that cortical and thalamic cells fire prolonged discharges in phase with the "spike" component, whereas the "wave" is characterized by a silence in all cell types (Pollen, 1964;Steriade, 1974;Avoli et al, 1983;McLachlan et al, 1984;Buzsáki et al, 1990;Inoue et al, 1993). Electrophysiological recordings also indicate that spindle oscillations, which are generated by thalamic circuits (Steriade et al, 1990, can be transformed gradually into SW discharges, and all manipulations that promote or antagonize spindles have the same effect on SW (Kostopoulos et al, 1981a,b;McLachlan et al, 1984).…”

Section: Abstract: Computational Models; Thalamus; Cerebral Cortex; mentioning

confidence: 96%

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Spike-and-Wave Oscillations Based on the Properties of GABA_BReceptors

1998

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Neocortical and thalamic neurons are involved in the genesis of generalized spike-and-wave (SW) epileptic seizures. The cellular mechanism of SW involves complex interactions between intrinsic neuronal firing properties and multiple types of synaptic receptors, but because of the complexity of these interactions the exact details of this mechanism are unclear. In this paper these types of interactions were investigated by using biophysical models of thalamic and cortical neurons. It is shown first that, because of the particular activation properties of GABA B receptor-mediated responses, simulated field potentials can display SW waveforms if cortical pyramidal cells and interneurons generate prolonged discharges in synchrony, without any other assumptions. Here the "spike" component coincided with the synchronous firing, whereas the "wave" component was generated mostly by slow GABA B -mediated K ϩ currents. Second, the model suggests that intact thalamic circuits can be forced into a ϳ3 Hz oscillatory mode by corticothalamic feedback. Here again, this property was attributable to the characteristics of GABA B -mediated inhibition. Third, in the thalamocortical system this property can lead to generalized ϳ3 Hz oscillations with SW field potentials. The oscillation consisted of a synchronous prolonged firing in all cell types, interleaved with a ϳ300 msec period of neuronal silence, similar to experimental observations during SW seizures. This model suggests that SW oscillations can arise from thalamocortical loops in which the corticothalamic feedback indirectly evokes GABA B -mediated inhibition in the thalamus. This mechanism is shown to be consistent with a number of different experimental models, and experiments are suggested to test its consistency.

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Section: Similarities With Experimental Models Of Spike and Wavesupporting

confidence: 89%

Section: Suppression Of Intracortical Gaba a -Mediated Inhibition Leasupporting

confidence: 55%

Section: Abstract: Computational Models; Thalamus; Cerebral Cortex; mentioning

confidence: 96%

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Spike-and-Wave Oscillations Based on the Properties of GABA_BReceptors

1998

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“…The firing rate of striatal neurons can be affected by the presence of high-voltage spindles (HVS), an 'idling' network state that broadly engages the cortex, basal ganglia, and thalamus (for example, Berke et al, 2004;Dejean et al, 2007), and whose incidence is affected by changes in striatal dopamine transmission (Buzsáki et al, 1990). Although the results present above excluded HVS episodes, we found that including them did not substantially change our findings (Supplementary Figure S2B).…”

Section: Drug Effects On Neuronal Firing Ratesmentioning

confidence: 73%

Opposite Effects of Stimulant and Antipsychotic Drugs on Striatal Fast-Spiking Interneurons

Wiltschko

Pettibone

Berke

2010

Neuropsychopharmacol

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Psychomotor stimulants and typical antipsychotic drugs have powerful but opposite effects on mood and behavior, largely through alterations in striatal dopamine signaling. Exactly how these drug actions lead to behavioral change is not well understood, as previous electrophysiological studies have found highly heterogeneous changes in striatal neuron firing. In this study, we examined whether part of this heterogeneity reflects the mixture of distinct cell types present in the striatum, by distinguishing between medium spiny projection neurons (MSNs) and presumed fast-spiking interneurons (FSIs), in freely moving rats. The response of MSNs to both the stimulant amphetamine (0.5 or 2.5 mg/kg) and the antipsychotic eticlopride (0.2 or 1.0 mg/kg) remained highly heterogeneous, with each drug causing both increases and decreases in the firing rate of many MSNs. By contrast, FSIs showed a far more uniform, dose-dependent response to both drugs. All FSIs had decreased firing rate after high eticlopride. After high amphetamine most FSIs increased firing rate, and none decreased. In addition, the activity of the FSI population was positively correlated with locomotor activity, whereas the MSN population showed no consistent response. Our results show a direct relationship between the psychomotor effects of dopaminergic drugs and the firing rate of a specific striatal cell population. Striatal FSIs may have an important role in the behavioral effects of these drugs, and thus may be a valuable target in the development of novel therapies.

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“…Moreover, dopamine D2 receptor antagonists have been found to increase spindle activity in rodents [80], which suggests that excessive dopaminergic activity may be associated with reduced spindle activity.…”

Section: Discussionmentioning

confidence: 99%

Schizophrenia as a disturbance of cortical sensory maps

Vukadinovic

2012

Translational Neuroscience

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Schizophrenia is a disorder characterized by a variety of symptoms, which among others include hallucinations, delusions and passivity experiences. It has been found that individuals with schizophrenia misattribute their own thoughts and actions to an outside agency (source monitoring deficits), which could account for psychotic experiences such as that of hearing voices. In order to explain the source-monitoring deficits as well as psychosis, it has been proposed that mechanisms that enable anticipation and recognition of sensory consequences of one's own actions are impaired in schizophrenia. Importantly, such mechanisms may require accurate cortical sensory representations such as in the primary somatosensory cortex (S1). The establishment and maintenance of cortical sensory representations has been found to utilize a sleep-related brain rhythm known as spindling. Namely, in the perinatal period in humans and animals, and possibly also thereafter, spontaneous activity in the sensory periphery drives spindle activity in the developing cortical sensory areas, which then contributes to the formation of sensory representations that match bodily features. For example, muscle twitch-spindle sequences during sleep facilitate the formation and maintenance of S1 in accordance with the layout of musculature. This process has been proposed to continue throughout the lifespan and may be particularly important during periods of bodily changes (adolescence, menopause). In schizophrenia, the amount of sleep spindle activity is markedly reduced, which would be expected to result in insufficient cortical sensory representations and have relevance for the relative inability of individuals with schizophrenia to accurately recognize self-initiated actions.

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Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker

Cited by 209 publications

References 89 publications

Spike-and-Wave Oscillations Based on the Properties of GABA_BReceptors

Spike-and-Wave Oscillations Based on the Properties of GABA_BReceptors

Opposite Effects of Stimulant and Antipsychotic Drugs on Striatal Fast-Spiking Interneurons

Schizophrenia as a disturbance of cortical sensory maps

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Petit mal epilepsy and parkinsonian tremor: Hypothesis of a common pacemaker

Cited by 209 publications

References 89 publications

Spike-and-Wave Oscillations Based on the Properties of GABABReceptors

Spike-and-Wave Oscillations Based on the Properties of GABABReceptors

Opposite Effects of Stimulant and Antipsychotic Drugs on Striatal Fast-Spiking Interneurons

Schizophrenia as a disturbance of cortical sensory maps

Contact Info

Product

Resources

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Spike-and-Wave Oscillations Based on the Properties of GABA_BReceptors

Spike-and-Wave Oscillations Based on the Properties of GABA_BReceptors