Peter Mitchell and the ox phos wars

Qc, John Prebble

doi:10.1016/s0968-0004(02)02059-5

Cited by 42 publications

(10 citation statements)

References 12 publications

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“…Obtaining these extra protons for coupling presents another insurmountable problem for the chemiosmotic theory. With this background, it is now possible to historically understand why Mitchell refused to accept the higher values of H + /O and H + /ATP ratios than the ones he had postulated in his theory, even in the face of the most incontrovertible experimental evidence, as documented by Prebble [ 49 ]. These stoichiometries were central and fundamental to chemiosmosis, and acceptance of the higher numbers would have created a severe energy crisis for the chemiosmotic theory and sounded the death-knell for it.…”

Section: Fundamental Consequences Of the Torsional Mechanism The mentioning

confidence: 99%

The New Unified Theory of ATP Synthesis/Hydrolysis and Muscle Contraction, Its Manifold Fundamental Consequences and Mechanistic Implications and Its Applications in Health and Disease

Nath

2008

IJMS

128

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Complete details of the thermodynamics and molecular mechanisms of ATP synthesis/hydrolysis and muscle contraction are offered from the standpoint of the torsional mechanism of energy transduction and ATP synthesis and the rotation-uncoiling-tilt (RUT) energy storage mechanism of muscle contraction. The manifold fundamental consequences and mechanistic implications of the unified theory for oxidative phosphorylation and muscle contraction are explained. The consistency of current mechanisms of ATP synthesis and muscle contraction with experiment is assessed, and the novel insights of the unified theory are shown to take us beyond the binding change mechanism, the chemiosmotic theory and the lever arm model. It is shown from first principles how previous theories of ATP synthesis and muscle contraction violate both the first and second laws of thermodynamics, necessitating their revision. It is concluded that the new paradigm, ten years after making its first appearance, is now perfectly poised to replace the older theories. Finally, applications of the unified theory in cell life and cell death are outlined and prospects for future research are explored. While it is impossible to cover OPEN ACCESS Int. J. Mol. Sci. 2008, 9 1785 each and every specific aspect of the above, an attempt has been made here to address all the pertinent details and what is presented should be sufficient to convince the reader of the novelty, originality, breakthrough nature and power of the unified theory, its manifold fundamental consequences and mechanistic implications, and its applications in health and disease.

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Section: Fundamental Consequences Of the Torsional Mechanism The mentioning

confidence: 99%

The New Unified Theory of ATP Synthesis/Hydrolysis and Muscle Contraction, Its Manifold Fundamental Consequences and Mechanistic Implications and Its Applications in Health and Disease

Nath

2008

IJMS

128

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“…The redox loops proposed by Mitchell were also wrong. More seriously, as noticed by many observers (Malmström 2000;Prebble 2002), both the export of protons from the mitochondria and the synthesis of ATP were seen by Mitchell as direct consequences of the orientation of chemical reactions. In the present model, the movement of protons is also due to their being pumped through the membrane, a consequence of the transconformation of the proteins involved in electron transport (Wikström 1977;Verkhovsky et al 1999).…”

Section: The Present Chemiosmotic Model Is Not the Model Proposed By mentioning

confidence: 93%

What history tells us XI. The complex history of the chemiosmotic theory

Morange

2007

J. Biosci.

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“…Entropy enthalpy compensation has been widely observed in different systems (Prebble 2002;Agutter and Wheatley 2004;Nielsen and Jensen 1990;Rottenberg 1979;Izumida and Okuda 2008). A close inspection reveals that till this date there has not been any satisfactory thermodynamic theory that explains this compensation.…”

Section: A New Insight Towards Enthalpy Entropy Compensationmentioning

confidence: 99%

“…A kinetically coupled reaction pair has common intermediate (chemical species). While this kinetic nomenclature for coupling has a broad range of validity, it fails to interpret coupling reactions in absence of common intermediates this being a fundamental attribute of all forms of chemisomotic controls (Prebble 2002). There is however a general approach based on near equilibrium thermodynamics that permits an explicit definition of thermodynamic coupling.…”

Section: Introductionmentioning

confidence: 99%

Finite time thermodynamic coupling in a biochemical network

Dasgupta

2014

Syst Synth Biol

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The paper describes some thermodynamic constrains and relations in biochemical or metabolic network and provides a basis for entropy enthalpy compensation. Conventional definition of macroscopic forces and fluxes leads to a paradox namely, non-existence of positive efficiency of a chemically driven process. This paradox is resolved by deriving an appropriate definition of macroscopic force using the local balance equations. Entropy enthalpy compensation, whose thermodynamic basis is so far unclear, also follows. The method provides an account of how reactive pathways are coupled, the strength of coupling between a pathway pair depending on the product of their respective enthalpies. The obligatory role of the presence of a common chemical intermediate in defining coupling becomes unnecessary; such intermediate-free coupling being a key feature of metabolic energy transduction. The redefined flux and force can also be exploited to explain surface to volume ratio dependence of coupled networks. Lastly, the thermodynamic rationale for the Bergman's eco-geographic rule, namely the reduced ability of larger animals to avoid stress follows from the generalized expression for coupling coefficients. Higher surface to volume ratio is shown to make the organism resistant to external perturbations.

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Peter Mitchell and the ox phos wars

Cited by 42 publications

References 12 publications

The New Unified Theory of ATP Synthesis/Hydrolysis and Muscle Contraction, Its Manifold Fundamental Consequences and Mechanistic Implications and Its Applications in Health and Disease

The New Unified Theory of ATP Synthesis/Hydrolysis and Muscle Contraction, Its Manifold Fundamental Consequences and Mechanistic Implications and Its Applications in Health and Disease

What history tells us XI. The complex history of the chemiosmotic theory

Finite time thermodynamic coupling in a biochemical network

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