Modeling and simulation of heterogeneous systems are faced with the problems of long modeling and simulation cycle, complex and changeable modeling fields and complex domain knowledge. In order to support the requirements analysis and initial design of the system, build the system model as the only authoritative truth source throughout the whole life cycle, and quantitatively characterize the requirements, functions, structure and performance of the system, this paper proposes an agile modeling and simulation technology for heterogeneous systems based on the meta-model modeling method, and on this basis, constructs an agile modeling and simulation system framework for heterogeneous systems.