PET should not replace routine SPECT MPS for the assessment of patients with known or suspected CAD

Stirrup, James; Underwood, S. Richard

doi:10.1007/s12350-017-1023-8

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…The advantage of SPECT in diagnosing CMVD is its higher sensitivity. Compared with PET, SPECT is cheaper ( 30 ), so it is more frequently-used in the clinic.…”

Section: Research Progress Of Imaging Methods For Detection Of Microvascular Angina Pectorismentioning

confidence: 99%

Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients

Feng

et al. 2021

Front. Cardiovasc. Med.

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Diabetes is a complex metabolic disease characterized by hyperglycemia. Its complications are various, often involving the heart, brain, kidney, and other essential organs. At present, the number of diabetic patients in the world is growing day by day. The cardiovascular disease caused by diabetes has dramatically affected the quality of life of diabetic patients. It is the leading cause of death of diabetic patients. Diabetic patients often suffer from microvascular angina pectoris without obstructive coronary artery disease. Still, there are typical ECG ischemia and angina pectoris, that is, chest pain and dyspnea under exercise. Unlike obstructive coronary diseases, nitrate does not affect chest pain caused by coronary microvascular angina in most cases. With the increasing emphasis on diabetic microvascular angina, the need for accurate diagnosis of the disease is also increasing. We can use SPECT, PET, CMR, MCE, and other methods to evaluate coronary microvascular function. SPECT is commonly used in clinical practice, and PET is considered the gold standard for non-invasive detection of myocardial blood flow. This article mainly introduces the research progress of these imaging methods in detecting microvascular angina in diabetic patients.

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“…The advantage of SPECT in diagnosing CMVD is its higher sensitivity. Compared with PET, SPECT is cheaper ( 30 ), so it is more frequently-used in the clinic.…”

Section: Research Progress Of Imaging Methods For Detection Of Microvascular Angina Pectorismentioning

confidence: 99%

Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients

Feng

et al. 2021

Front. Cardiovasc. Med.

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“…A normal study is a prognostic indicator of a <1% annual risk of a coronary event, while an abnormal MPS indicates a seven-fold likelihood of acute myocardial infarction within 10 years when compared with the normal group. 3 Radiation doses have reduced significantly in recent years, as for all imaging associated with ionising radiation.…”

Section: Single-photon Emission Computed Tomography Myocardial Perfus...mentioning

confidence: 99%

Cardiac imaging: 2022 update

Storey

2022

Aust J Gen Pract

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Functional characterization of human brown adipose tissue metabolism

Richard

Pallubinsky

Blondin

2020

Biochemical Journal

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Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

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PET should not replace routine SPECT MPS for the assessment of patients with known or suspected CAD

Cited by 4 publications

References 24 publications

Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients

Research Progress of Imaging Methods for Detection of Microvascular Angina Pectoris in Diabetic Patients

Cardiac imaging: 2022 update

Functional characterization of human brown adipose tissue metabolism

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