Pet scanning in head and neck oncology: A review

McGuirt, W. Frederick; Greven, Kathryn M.; Williams, Daniel W.; Keyes, John W.; Watson, Nat E.; Cappellari, James O.; Geisinger, Kim R.

doi:10.1002/(sici)1097-0347(199805)20:3<208::aid-hed5>3.0.co;2-4

Cited by 123 publications

(55 citation statements)

References 17 publications

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“…These were asymmetrical in distribution and were considered positive nodal metastases; however, 18 F-FDG PET/CT clearly localised these to brown fat planes and muscle uptake (Table 1). It is well known that nonspecific uptake in brown fat planes and muscle attachment sites ( Figure 2E) is a common cause of false-positive results (Engel et al, 1996;Kostakoglu et al, 1996;McGuirt et al, 1998). This false-positive feature has a critical impact on nodal staging of head and neck tumours (Helmberger et al, 1996;Myers et al, 1998;Hannah et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Impact of combined 18F-FDG PET/CT in head and neck tumours

et al. 2005

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To compare the interobserver agreement and degree of confidence in anatomical localisation of lesions using 2-[fluorine-18]fluoro-2-deoxy- D -glucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) and 18 F-FDG PET alone in patients with head and neck tumours. A prospective study of 24 patients (16 male, eight female, median age 59 years) with head and neck tumours was undertaken. 18 F-FDG PET/CT was performed for staging purposes. 2D images were acquired over the head and neck area using a GE Discovery LS™ PET/CT scanner. 18 F-FDG PET images were interpreted by three independent observers. The observers were asked to localise abnormal 18 F-FDG activity to an anatomical territory and score the degree of confidence in localisation on a scale from 1 to 3 (1=exact region unknown; 2=probable; 3=definite). For all 18 F-FDG-avid lesions, standardised uptake values (SUVs) were also calculated. After 3 weeks, the same exercise was carried out using 18 F-FDG PET/CT images, where CT and fused volume data were made available to observers. The degree of interobserver agreement was measured in both instances. A total of six primary lesions with abnormal 18 F-FDG uptake (SUV range 7.2–22) were identified on 18 F-FDG PET alone and on 18 F-FDG PET/CT. In all, 15 nonprimary tumour sites were identified with 18 F-FDG PET only (SUV range 4.5–11.7), while 17 were identified on 18 F-FDG PET/CT. Using 18 F-FDG PET only, correct localisation was documented in three of six primary lesions, while 18 F-FDG PET/CT correctly identified all primary sites. In nonprimary tumour sites, 18 F-FDG PET/CT improved the degree of confidence in anatomical localisation by 51%. Interobserver agreement in assigning primary and nonprimary lesions to anatomical territories was moderate using 18 F-FDG PET alone (kappa coefficients of 0.45 and 0.54, respectively), but almost perfect with 18 F-FDG PET/CT (kappa coefficients of 0.90 and 0.93, respectively). We conclude that 18 F-FDG PET/CT significantly increases interobserver agreement and confidence in disease localisation of 18 F-FDG-avid lesions in patients with head and neck cancers.

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Section: Discussionmentioning

confidence: 99%

Impact of combined 18F-FDG PET/CT in head and neck tumours

et al. 2005

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“…17,27,28 However, these studies only occasionally included patients with oral carcinoma. Moreover, the predominant therapeutic modality in all of these series was irradiation.…”

Section: Discussionmentioning

confidence: 99%

Detection of recurrent oral squamous cell carcinoma by [¹⁸F]‐2‐fluorodeoxyglucose‐positron emission tomography

Kunkel¹,

Forster²,

Reichert³

et al. 2003

Cancer

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The morphologies of the fracture surface under impact and flexural testing of Mg(OH)2/Polypropylene (PP) composites and their modified composites were investigated by scanning electron microscopy. Experimental results indicated that addition of functionalized polypropylene (FPP) and acrylic acid (AA) and the formation of in situ FPP changed the fracture morphologies of Mg(OH)2/PP composites. We believe that addition of these modifiers improved the interfacial interaction and enhanced the interface adhesion between the particle and the matrix in Mg(OH)2/PP composites. The degree of improvement was more significant in Mg(OH)2/PP composites modified by the formation of in situ FPP. At low Mg(OH)2 content, 2 phr AA exhibited a marked effect, but at high Mg(OH)2 content, 4 phr AA afforded good effect. Due to the improved interface adhesion by interface interactions the fracture mechanism transformed from interface debonded fracture into a matrix fracture. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 2148–2159, 2003

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“…1 In contrast to anatomic imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI), FDG-PET imaging is based on metabolism and tissue perfusion. 2 PET is performed using a radioactively labeled glucose analog (FDG) that can be localized accurately due to its emission of positrons. Because FDG is taken up by tissue in the same fashion as normal glucose, this radioactive tracer becomes concentrated in cells with high levels of glucose usage.…”

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confidence: 99%

“…As a result, neoplasms are reliably distinguishable from surrounding tissues on FDG-PET imaging. 2 The role of FDG-PET in the imaging of head and neck carcinoma has been thoroughly investigated. Numerous studies have demonstrated the value of FDG-PET in detecting and staging initial disease and in detecting recurrent disease after radiotherapy.…”

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confidence: 99%

The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor

Rusthoven

Koshy

Paulino

2004

Cancer

299

178

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BACKGROUNDThe authors performed a comprehensive review of the efficacy of fluorodeoxyglucose positron emission tomography (FDG‐PET) in the detection of primary tumors in patients with cervical metastases from unknown primary tumors.METHODSSixteen studies (involving a total of 302 patients) published between 1994 and 2003 were reviewed. These studies evaluated the role of FDG‐PET in the detection of unknown primary tumors after conventional workup. In all studies, conventional workup included either panendoscopy or computed tomographic/magnetic resonance imaging, and in 10 of 16 studies, both of these diagnostic techniques were performed before diagnosis.RESULTSThe overall sensitivity, specificity, and accuracy rates of FDG‐PET in detecting unknown primary tumors were 88.3%, 74.9%, and 78.8%, respectively. Furthermore, FDG‐PET detected 24.5% of tumors that were not apparent after conventional workup. FDG‐PET imaging also led to the detection of previously unrecognized metastases in 27.1% of patients (regional, 15.9%; distant, 11.2%). FDG‐PET had notably low specificity and a high false‐positive rate (39.3%) in the tonsils. In contrast, the false‐positive rates for FDG‐PET of the base of tongue and hypopharynx were only 21.4% and 8.3%, respectively. FDG‐PET exhibited decreased sensitivity to tumors in the base of tongue (81.5%). The sensitivity of this technique at other sites was 90.5%.CONCLUSIONSFDG‐PET detected primary tumors that went undetected by other modalities in approximately 25% of cases and was sensitive in the detection of previously unrecognized regional or distant metastases in 27% of cases. FDG‐PET had low specificity for tonsillar tumors and low sensitivity for base‐of‐tongue malignancies. Cancer 2004. © 2004 American Cancer Society.

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Pet scanning in head and neck oncology: A review

Cited by 123 publications

References 17 publications

Impact of combined 18F-FDG PET/CT in head and neck tumours

Impact of combined 18F-FDG PET/CT in head and neck tumours

Detection of recurrent oral squamous cell carcinoma by [¹⁸F]‐2‐fluorodeoxyglucose‐positron emission tomography

The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor

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Pet scanning in head and neck oncology: A review

Cited by 123 publications

References 17 publications

Impact of combined 18F-FDG PET/CT in head and neck tumours

Impact of combined 18F-FDG PET/CT in head and neck tumours

Detection of recurrent oral squamous cell carcinoma by [18F]‐2‐fluorodeoxyglucose‐positron emission tomography

The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor

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Detection of recurrent oral squamous cell carcinoma by [¹⁸F]‐2‐fluorodeoxyglucose‐positron emission tomography