PET scan in the therapeutic strategy

Haı̈oun, Corinne; Itti, Emmanuel; Rahmouni, Alaim; Meignan, Michel; Reyes, F

doi:10.1038/sj.thj.6200442

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…In a review performed by Haioun et al, results obtained by using PET/CT alone were in line with conventional imaging and BMB in only 80% of the cases. Using PET/CT alone yielded superior results to both methods in 8% of the cases and inferior results to both of them in 12 of the cases [ 23 ]. In a metaanalysis of 587 patients that evaluated PET/CT results in detection of bone marrow involvement in HL and aNHL, this method was designated as a good, but not excellent, tool [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin’s or Non-Hodgkin’s Lymphoma?

Çetin¹,

Çıkrıkçıoğlu²,

Özkan³

et al. 2015

Tjh

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Objective:Positron emission tomography and computed tomography (PET/CT) has become an important part of staging and treatment evaluation algorithms of lymphoma. We aimed to compare the results of PET/CT with bone marrow biopsy (BMB) with respect to bone marrow involvement (BMI) in patients with Hodgkin’s lymphoma (HL) and aggressive non-Hodgkin’s lymphoma (aNHL).Materials and Methods:The medical files of a total of 297 patients diagnosed with HL or aNHL and followed at the hematology clinics of 3 major hospitals in İstanbul between 2008 and 2012 were screened retrospectively and 161 patients with classical HL and aNHL were included in the study. The patients were referred for PET/CT and BMB at the initial staging. BMB was performed as the reference standard for the evaluation of BMI. Results:There were 61 (38%) HL and 100 (62%) aNHL patients. Concordant results were revealed between PET/CT and BMB in 126 patients (78%) (52 HL, 74 aNHL), 20 with positive PET/CT and BMB results and 106 with negative PET/CT and BMB results. There were discordant results in 35 patients (9 HL, 26 aNHL), 16 of them with positive BMB and negative PET/CT results and 19 of them with negative BMB and positive PET/CT results.Conclusion:We observed that PET/CT is effective to detect BMI, despite it alone not being sufficient to evaluate BMI in HL and aNHL. Bone marrow trephine biopsy and PET/CT should be considered as mutually complementary methods for detection of BMI in patients with lymphoma. In suspected focal involvement, combining biopsy and PET/CT might improve staging results.

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Section: Discussionmentioning

confidence: 99%

Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin’s or Non-Hodgkin’s Lymphoma?

Çetin¹,

Çıkrıkçıoğlu²,

Özkan³

et al. 2015

Tjh

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“…For the post-transplant period, the role of six cycles of rituximab versus observation is being tested in a second randomization step. 31 Whether these fi ndings will ultimately indicate that different treatment strategies are appropriate, including early SCT, must be shown in prospective trials. 30 FDG-PET positivity during induction or after completion of induction therapy implies an increased risk of relapse.…”

Section: Relapsed Refractory Diseasementioning

confidence: 99%

Hodgkin's disease and non-Hodgkin's lymphoma

Finke¹

2009

Hematopoietic Stem Cell Transplantation in Clinical Practice

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“…PET resulted in a change of therapy in 8% of patients [28]. A review by Haioun et al concluded that PET alone is concordant with conventional imaging and bone marrow biopsy in only 80% of cases, superior to both in 8% and inferior in 12% [29]. …”

Section: Stagingmentioning

confidence: 99%